| Necrotizing enterocolitis induced by local circulatory interruption in the ileum of neonatal piglets. | |
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MedLine Citation:
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PMID: 1561146 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Occlusion of groups of vessels in the mesenteric vascular arcades of distal ileum for 48 h induced necrotizing enterocolitis lesions in low birth weight, spontaneously delivered, neonatal piglets. Lesion severity increased with numbers of adjacent groups of vessels occluded and with proximity to the ileocecal junction. A previously undescribed feature, "prepneumatosis," was confined to the lymphatic vessels of the submucosa and serosa. This feature closely resembled the position, shape, and distribution of classical pneumatosis intestinalis. Occlusion of vessels for 30 min followed by reperfusion did not induce any detectable changes 48 h later. Identical procedures (48-h occlusions) did not induce any detectable changes in 35-kg pigs. |
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Authors:
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P D Sibbons; L Spitz; D van Velzen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric pathology / affiliated with the International Paediatric Pathology Association Volume: 12 ISSN: 0277-0938 ISO Abbreviation: Pediatr Pathol Publication Date: 1992 Jan-Feb |
Date Detail:
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Created Date: 1992-05-14 Completed Date: 1992-05-14 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8303527 Medline TA: Pediatr Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-14 Citation Subset: IM |
Affiliation:
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Department of Paediatric Surgery, Institute of Child Health, London, England. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn / physiology* Birth Weight / physiology Enterocolitis, Pseudomembranous / etiology*, pathology, physiopathology Ileum / blood supply, pathology, physiology* Mesenteric Arteries / physiology Mesenteric Veins / physiology Regional Blood Flow Reperfusion Injury / pathology, physiopathology Swine / physiology* |
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