Document Detail


Necrotizing enterocolitis is associated with ureaplasma colonization in preterm infants.
MedLine Citation:
PMID:  21258263     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The study objective was to determine whether Ureaplasma respiratory tract colonization of preterm infants <33 wk gestation is associated with an increased risk for necrotizing enterocolitis (NEC). One or more tracheal or nasopharyngeal aspirates for Ureaplasma culture and PCR were obtained during the first week of life from 368 infants <33 wk gestation enrolled from 1999 to 2003 or from 2007 to 2009. NEC Bell stage ≥ 2 was confirmed by radiological criteria, and pathology, if available. Cord serum samples were analyzed for IL-6 and IL-1β concentrations, and placentas were reviewed for histological chorioamnionitis in the first cohort. NEC was confirmed in 29 of 368 (7.9%) of the combined cohorts. The incidence of NEC was 2.2-fold higher in Ureaplasma-positive (12.3%) than Ureaplasma-negative (5.5%) infants <33 wk (OR, 2.43; 95% CI, 1.13-5.2; p = 0.023) and 3.3-fold higher in Ureaplasma-positive (14.6%) than Ureaplasma-negative (4.4%) infants ≤ 28 wk (OR, 3.67; 95% CI, 1.36-9.93; p = 0.01). Age of onset, hematologic parameters at onset, and NEC severity were similar between Ureaplasma-positive and negative infants. Cord serum IL-6 and IL-1β concentrations were significantly higher in Ureaplasma-positive than in Ureaplasma-negative NEC-affected infants. Ureaplasma may be a factor in NEC pathogenesis in preterm infants by contributing to intestinal mucosal injury and/or altering systemic or local immune responses.
Authors:
Adora C Okogbule-Wonodi; George W Gross; Chen-Chih J Sun; Alexander G Agthe; Li Xiao; Ken B Waites; Rose Marie Viscardi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pediatric research     Volume:  69     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-15     Completed Date:  2011-07-25     Revised Date:  2014-03-31    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  442-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Bacteriological Techniques
Baltimore
Chi-Square Distribution
Enterocolitis, Necrotizing / epidemiology,  immunology,  microbiology*
Female
Fetal Blood / immunology
Gestational Age
Humans
Incidence
Infant, Extremely Low Birth Weight
Infant, Newborn
Infant, Premature*
Infant, Very Low Birth Weight
Inflammation Mediators / blood
Interleukin-1beta / blood
Interleukin-6 / blood
Male
Odds Ratio
Polymerase Chain Reaction
Prospective Studies
Respiratory Tract Infections / epidemiology,  immunology,  microbiology*
Risk Assessment
Risk Factors
Ureaplasma / genetics,  isolation & purification,  pathogenicity*
Ureaplasma Infections / epidemiology,  immunology,  microbiology*
Grant Support
ID/Acronym/Agency:
5R01A1072577//PHS HHS; HL087166/HL/NHLBI NIH HHS; HL71113/HL/NHLBI NIH HHS; R01 AI072577/AI/NIAID NIH HHS; R01 HL071113/HL/NHLBI NIH HHS; R01 HL087166/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/IL6 protein, human; 0/Inflammation Mediators; 0/Interleukin-1beta; 0/Interleukin-6
Comments/Corrections
Comment In:
Pediatr Res. 2011 Oct;70(4):423-4; author reply 424   [PMID:  21885937 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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