Document Detail

Necrotising leukoencephalopathy complicating treatment of childhood leukaemia.
MedLine Citation:
PMID:  6693915     Owner:  NLM     Status:  MEDLINE    
Nine children treated for acute leukemia or lymphosarcoma developed subacute encephalopathy starting with listlessness, depression and impairment of speech. Walking difficulties, ataxia, spasticity and sphincter disorders developed later. Transient intracranial hypertension and abnormal movements respectively developed in two patients. EEG frontal slow waves, raised CSF protein, abnormal white matter radioisotope uptake and CT scan hypodensity with patchy contrast enhancement were evident at the onset. Later, dilated ventricles and calcification appeared in the younger patients. Post-mortem neuropathological studies of three patients disclosed predominantly perivascular myelin loss in areas of white matter necrosis, abnormalities of small vessels and numerous axonal swellings. The spinal cord showed secondary degeneration of the corticospinal tracts. Analysis of the aetiological factors in this series points to the prevailing danger of cranial radiotherapy, probably increased by the young age of patients and by associated drug administration.
O Robain; O Dulac; J P Dommergues; F Bernaudin; K Diebler; C Kalifa; J Poirier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  47     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-03-19     Completed Date:  1984-03-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  65-72     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Brain / pathology
Cerebral Arteries / pathology
Child, Preschool
Combined Modality Therapy
Leukemia / complications*,  therapy
Leukoencephalopathy, Progressive Multifocal / pathology*
Nerve Degeneration
Nerve Fibers, Myelinated / ultrastructure
Neural Pathways / pathology
Radiotherapy Dosage
Spinal Cord / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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