| Necrotising leukoencephalopathy complicating treatment of childhood leukaemia. | |
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MedLine Citation:
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PMID: 6693915 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nine children treated for acute leukemia or lymphosarcoma developed subacute encephalopathy starting with listlessness, depression and impairment of speech. Walking difficulties, ataxia, spasticity and sphincter disorders developed later. Transient intracranial hypertension and abnormal movements respectively developed in two patients. EEG frontal slow waves, raised CSF protein, abnormal white matter radioisotope uptake and CT scan hypodensity with patchy contrast enhancement were evident at the onset. Later, dilated ventricles and calcification appeared in the younger patients. Post-mortem neuropathological studies of three patients disclosed predominantly perivascular myelin loss in areas of white matter necrosis, abnormalities of small vessels and numerous axonal swellings. The spinal cord showed secondary degeneration of the corticospinal tracts. Analysis of the aetiological factors in this series points to the prevailing danger of cranial radiotherapy, probably increased by the young age of patients and by associated drug administration. |
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Authors:
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O Robain; O Dulac; J P Dommergues; F Bernaudin; K Diebler; C Kalifa; J Poirier |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 47 ISSN: 0022-3050 ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 1984 Jan |
Date Detail:
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Created Date: 1984-03-19 Completed Date: 1984-03-19 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 65-72 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Antineoplastic Combined Chemotherapy Protocols / adverse effects Brain / pathology Cerebral Arteries / pathology Child Child, Preschool Combined Modality Therapy Female Humans Leukemia / complications*, therapy Leukoencephalopathy, Progressive Multifocal / pathology* Male Necrosis Nerve Degeneration Nerve Fibers, Myelinated / ultrastructure Neural Pathways / pathology Radiotherapy Dosage Spinal Cord / pathology |
| Comments/Corrections | |
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