| Necrotising enterocolitis: the state of the science. | |
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MedLine Citation:
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PMID: 17264459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Necrotizing enterocolitis is the most common gastrointestinal emergency of the neonate, affecting 5-10% of infants, yet the pathogenesis remains unclear. Widely accepted risk factors include prematurity, enteral feeds, bacterial colonization and mucosal injury. How these or other yet identified factors come together to create the classic clinical and pathologic features is the subject of much research. The activation of the cytokine cascade, in part by bacterial ligands, appears to play a key role in mucosal injury. Two mediators that may also contribute are platelet activating factor and intestinal toll-like receptors. Short chain fatty acids, the products of bacterial fermentation of carbohydrates, have been thought to cause mucosal injury. Overgrowth of pathogenic bacteria in the face of a decreased commensal population may play a key role. A current focus of clinical research involves probiotics, enterally fed forms of commsenal bacteria. This may set the stage for a healthier intestinal ecosystem and possibly, decreased risk of NEC. |
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Authors:
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Kathleen Gibbs; Jing Lin; Ian R Holzman |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Indian journal of pediatrics Volume: 74 ISSN: 0973-7693 ISO Abbreviation: Indian J Pediatr Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-31 Completed Date: 2007-02-22 Revised Date: 2009-07-15 |
Medline Journal Info:
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Nlm Unique ID: 0417442 Medline TA: Indian J Pediatr Country: India |
Other Details:
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Languages: eng Pagination: 67-72 Citation Subset: IM |
Affiliation:
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Division of Newborn Medicine, Department of Pediatrics, The Mount Sinai School of Medicine, New York, NY 10029, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Combined Modality Therapy Enteral Nutrition Enterocolitis, Necrotizing / diagnosis*, mortality, therapy* Fatty Acids, Volatile / metabolism Female Fluid Therapy / methods Humans Infant, Newborn Infant, Premature* Infant, Premature, Diseases / diagnosis, mortality, therapy Inflammation Mediators / analysis Intestinal Mucosa / pathology* Male Probiotics / administration & dosage* Prognosis Risk Factors Severity of Illness Index Survival Rate Toll-Like Receptors / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Volatile; 0/Inflammation Mediators; 0/Toll-Like Receptors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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