Document Detail

Necrotising enterocolitis: the state of the science.
MedLine Citation:
PMID:  17264459     Owner:  NLM     Status:  MEDLINE    
Necrotizing enterocolitis is the most common gastrointestinal emergency of the neonate, affecting 5-10% of infants, yet the pathogenesis remains unclear. Widely accepted risk factors include prematurity, enteral feeds, bacterial colonization and mucosal injury. How these or other yet identified factors come together to create the classic clinical and pathologic features is the subject of much research. The activation of the cytokine cascade, in part by bacterial ligands, appears to play a key role in mucosal injury. Two mediators that may also contribute are platelet activating factor and intestinal toll-like receptors. Short chain fatty acids, the products of bacterial fermentation of carbohydrates, have been thought to cause mucosal injury. Overgrowth of pathogenic bacteria in the face of a decreased commensal population may play a key role. A current focus of clinical research involves probiotics, enterally fed forms of commsenal bacteria. This may set the stage for a healthier intestinal ecosystem and possibly, decreased risk of NEC.
Kathleen Gibbs; Jing Lin; Ian R Holzman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  74     ISSN:  0973-7693     ISO Abbreviation:  Indian J Pediatr     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-31     Completed Date:  2007-02-22     Revised Date:  2009-07-15    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  IM    
Division of Newborn Medicine, Department of Pediatrics, The Mount Sinai School of Medicine, New York, NY 10029, USA.
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MeSH Terms
Combined Modality Therapy
Enteral Nutrition
Enterocolitis, Necrotizing / diagnosis*,  mortality,  therapy*
Fatty Acids, Volatile / metabolism
Fluid Therapy / methods
Infant, Newborn
Infant, Premature*
Infant, Premature, Diseases / diagnosis,  mortality,  therapy
Inflammation Mediators / analysis
Intestinal Mucosa / pathology*
Probiotics / administration & dosage*
Risk Factors
Severity of Illness Index
Survival Rate
Toll-Like Receptors / metabolism
Reg. No./Substance:
0/Fatty Acids, Volatile; 0/Inflammation Mediators; 0/Toll-Like Receptors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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