Document Detail


Necrotising enterocolitis in HIV-exposed and non-exposed infants : clinical presentation and histopathological features.
MedLine Citation:
PMID:  22483319     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Background: Necrotizing Enterocolitis (NEC) is the most common gastrointestinal emergency in neonates and is associated with significant morbidity and mortality. An association between HIV-positive maternal status and increased risk of NEC in preterm infants has been described and antiretroviral therapy has been proposed as an independent risk factor. Aim: To compare the clinical presentation and histopathological features of necrotizing enterocolitis in HIV exposed and un-exposed infants. Method: A retrospective study of archival material from the NHLS histopathology laboratory in Tygerberg hospital / Stellenbosch University from 1992 to 2008. All surgical specimens from infants who presented to paediatric surgery for a laparotomy and bowel resection for NEC and in whom the HIV status was known were included in the study. Results: In the 37 cases which fulfilled these criteria, male gender was over-represented in the study population (67%). Non steroidal anti inflammatory drugs (NSAID's) appeared to play a significant role in the development of surgical NEC in infants who were not exposed to HIV, but HIV-exposed infants had a significantly poorer survival rate. There was no significant difference in the histopathology between HIV-exposed and non-exposed infants, and Cytomegalovirus infection was not identified in any of the cases studied.
Authors:
Mmaphuti Jackie Chokoe; Colleen Anne Wright; Juanita Bezuidenhout; Sam W Moore; Johan Smith
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-6
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  -     ISSN:  1093-5266     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
a Stellenbosch University,NHLS, Anatomical Pathology.
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