Document Detail

Necrotic volume increase and the early physiology of necrosis.
MedLine Citation:
PMID:  11913453     Owner:  NLM     Status:  MEDLINE    
Whether a lethally injured mammalian cell undergoes necrosis or apoptosis may be determined by the early activation of specific ion channels at the cell surface. Apoptosis requires K+ and Cl- efflux, which leads to cell shrinking, an active phenomenon termed apoptotic volume decrease (AVD). In contrast, necrosis has been shown to require Na+ influx through membrane carriers and more recently through stress-activated non-selective cation channels (NSCCs). These ubiquitous channels are kept dormant in viable cells but become activated upon exposure to free-radicals. The ensuing Na+ influx leads to cell swelling, an active response that may be termed necrotic volume increase (NVI). This review focuses on how AVD and NVI become conflicting forces at the beginning of cell injury, on the events that determine irreversibility and in particular, on the ion fluxes that decide whether a cell is to die by necrosis or by apoptosis.
L F Barros; T Hermosilla; J Castro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology     Volume:  130     ISSN:  1095-6433     ISO Abbreviation:  Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2002-03-26     Completed Date:  2002-04-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9806096     Medline TA:  Comp Biochem Physiol A Mol Integr Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  401-9     Citation Subset:  IM    
Centro de Estudios Científicos CECS, Valdivia, Chile.
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MeSH Terms
Chloride Channels / metabolism
Ion Transport
Potassium Channels / metabolism
Reg. No./Substance:
0/Chloride Channels; 0/Potassium Channels

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