Document Detail

Necrotic epithelial cells in proximal renal tubules of 2nd trimester fetuses: is this "acute tubular necrosis"?
MedLine Citation:
PMID:  22670176     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of this study is to describe the occurrence of necrotic tubular cells in kidneys of non-macerated fetuses.
METHODS: Description of histology and immunostaining results using C9 immunostain of proximal tubular epithelium of kidneys from 30 consecutive non-macerated fetuses' autopsies.
RESULTS: the gestational age ranged from 13 to 22 weeks. The mean gestational age was 18.6 weeks; the cause of death was acute chorioamnionitis in 13 cases (43.3%), termination of pregnancy for fetal anomalies in 13 (43.3%) and other causes in 4 (13.3%). Histology of the kidneys revealed vacuolation of proximal tubule epithelial cells (100%), dilatation of tubules (93.4%) and tubular cell necrosis (53.4%). C9 immunostaining was positive in 24 cases (80%) and was seen in all gestational ages.
CONCLUSIONS: These results indicate that tubular cell necrosis is not an uncommon finding in the kidneys of 2(nd) trimester fetuses and may represent acute tubular necrosis (ATN). C9 is a helpful marker in confirming this diagnosis. Future studies may further explore this preliminary observation.
Luiz Cesar Peres; Chitra Sethuraman; Mudher Al-Adnani; Marta Cecilia Cohen
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Publication Detail:
Type:  Journal Article     Date:  2012-04-16
Journal Detail:
Title:  International journal of clinical and experimental pathology     Volume:  5     ISSN:  1936-2625     ISO Abbreviation:  Int J Clin Exp Pathol     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-06     Completed Date:  2012-10-10     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101480565     Medline TA:  Int J Clin Exp Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  326-30     Citation Subset:  IM    
Department of Histopathology, Sheffield Children's Hospital NHS Foundation Trust, Sheffield, S10 2TH, United Kingdom.
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MeSH Terms
Biological Markers / analysis
Complement C9 / analysis
Epithelial Cells / immunology,  pathology*
Gestational Age
Kidney Tubular Necrosis, Acute / embryology,  immunology,  pathology*
Kidney Tubules, Proximal / embryology,  immunology,  pathology*
Pregnancy Trimester, Second
Reg. No./Substance:
0/Biological Markers; 0/Complement C9

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