Document Detail

Necrotic cell death in human amniotic cells infected by Listeria monocytogenes.
MedLine Citation:
PMID:  19309562     Owner:  NLM     Status:  MEDLINE    
Listeria monocytogenes can cause a placental-foetal infection that results in spontaneous abortion, premature labour, stillbirth, or neonatal sepsis and meningitis. Bacteria cross the maternofoetal barrier at the villous syncytiotrophoblast level and subsequently spread from the placenta to the fetus. L. monocytogenes is able to induce different kinds of death in a variety of cells. Murine hepatocytes, murine T and human B lymphocytes, and murine dendritic cells die by apoptosis, whereas bacterial infection of murine and human macrophages leads mainly to necrotic cell death. As we previously described the efficient infection and growth of L. monocytogenes in a human amniotic cell line, we investigated the fate of these cells in order to analyse the mode of cell death. Our results provide biochemical and morphological evidence of necrotic death induced by L. monocytogenes infection.
M G Ammendolia; F Superti; L Bertuccini; L Seganti; D Cipriani; C Longhi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of immunopathology and pharmacology     Volume:  22     ISSN:  0394-6320     ISO Abbreviation:  Int J Immunopathol Pharmacol     Publication Date:    2009 Jan-Mar
Date Detail:
Created Date:  2009-03-24     Completed Date:  2009-04-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911335     Medline TA:  Int J Immunopathol Pharmacol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  153-62     Citation Subset:  IM    
Department of Technology and Health, National Institute of Health, Rome, Italy.
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MeSH Terms
Amnion / microbiology*,  pathology*,  ultrastructure
Cell Line
L-Lactate Dehydrogenase / secretion
Listeria monocytogenes / pathogenicity*
Microscopy, Electron, Scanning
Reg. No./Substance:
EC Dehydrogenase

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