Document Detail


Necrosis of malignant gliomas after intratumoral injection of 201Tl in vivo in the rat.
MedLine Citation:
PMID:  7756674     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fourteen adult Fischer 344 rats were inoculated in vivo unilaterally in the caudate nucleus in the brain with malignant RG 2 glioma cells. By 3 weeks a tumor with a diameter of 3-6 mm normally develops. Ten animals which survived the repeated periods of anesthesia and thallium (Tl) injections (intratumorally three times of 201Tl, 15-23 days after inoculation) showed a prolonged retention of radioactivity at the site of injection with no uptake in other organs except for the kidneys. Singular circumscribed necroses were found post-mortem at the site of injection, comprising malignant glioma tumor tissue, which in six animals was absent, in three animals was markedly reduced in size compared with controls and in one animal had the expected size. In four animals metastases were found in distant locations in the brain; in three of these cases there was a retention of radioactivity in the tumor. The selective necrotizing effect on the tumor cells is interpreted as mainly due to emission of Auger electrons from intracellularly accumulated 201Tl, giving rise to very high energy deposition in the vicinity of the cell nucleus. The results should also have implications for the treatment of human malignant gliomas.
Authors:
H Sjöholm; K Ljunggren; R Adeli; A Brun; C Ceberg; S E Strand; L G Salford
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anti-cancer drugs     Volume:  6     ISSN:  0959-4973     ISO Abbreviation:  Anticancer Drugs     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-06-26     Completed Date:  1995-06-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100823     Medline TA:  Anticancer Drugs     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  109-14     Citation Subset:  IM; S    
Affiliation:
Department of Clinical Neurophysiology, University Hospital, Lund, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Neoplasms / pathology,  radionuclide imaging,  radiotherapy*
Caudate Nucleus* / pathology
Female
Glioma / pathology,  radionuclide imaging,  radiotherapy*
Injections, Intralesional
Linear Energy Transfer
Necrosis
Neoplasm Metastasis
Rats
Rats, Inbred F344
Stereotaxic Techniques
Thallium Radioisotopes / administration & dosage,  pharmacokinetics,  therapeutic use*
Tissue Distribution
Chemical
Reg. No./Substance:
0/Thallium Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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