Document Detail

Necrosis of the leg after intraarterial drug injection.
MedLine Citation:
PMID:  21500183     Owner:  NLM     Status:  MEDLINE    
Inadvertent intraarterial injections in the context of drug abuse can cause damage to the vascular system. The clinical picture depends on the drug properties and ranges from partial ischemia to necrosis of the affected extremity. There are no current evidence-based guidelines regarding the management of intraarterial drug injections. In many cases the concept of solving vasospasm after injection is based on the use of intraarterial application of prostaglandins. We report a case in which a mixture of drugs was injected into the left femoral artery. The patient arrived 24 hours later with ischemia of the left leg at our emergency department. Angiography showed that there was no blood flowing in the leg. Despite intraarterial application of vasodilatators, regional neurolysis and thrombolyis with urokinase major amputation was unavoidable. The outcome after inadvertent injection depends on certain drug properties and the delay between injection and the beginning of therapy.
T Betz; M Steinbauer; C Uhl; I Toepel
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  VASA. Zeitschrift für Gefässkrankheiten     Volume:  40     ISSN:  0301-1526     ISO Abbreviation:  VASA     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-18     Completed Date:  2011-06-07     Revised Date:  2012-10-19    
Medline Journal Info:
Nlm Unique ID:  0317051     Medline TA:  Vasa     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  163-6     Citation Subset:  IM    
Departement of Vascular Surgery Krankenhaus Barmherzige Brüder, Regensburg, Germany.
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MeSH Terms
Amphetamine-Related Disorders / complications*
Benzodiazepines / administration & dosage
Femoral Artery
Heroin Dependence / complications*
Injections, Intra-Arterial
Ischemia / etiology*,  pathology,  radiography,  surgery
Lower Extremity / blood supply*
Methamphetamine / administration & dosage
Substance Abuse, Intravenous / complications*
Treatment Outcome
Reg. No./Substance:
12794-10-4/Benzodiazepines; 537-46-2/Methamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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