| Necessity of interleukin-1beta converting enzyme cascade in taxotere-initiated death signaling. | |
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MedLine Citation:
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PMID: 9551718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Taxotere is a new type chemotherapeutic agent which targets tubulin. In the present study, we investigated the molecular machinery of taxotere-initiated death signaling. Taxotere induced cell death in mouse fibroblast L929 cells. Cell morphological analysis revealed that this effect showed characteristics of apoptotic and necrotic cell death. To further examine taxotere-induced cell death, we investigated the direct involvement of caspase. When cells were pretreated with the synthesized tetrapeptide inhibitor of caspase, YVAD-CHO (Ac-Tyr-Val-Ala-Asp-aldehyde: inhibitor of interleukin-1beta converting enzyme (ICE) subfamily) or DEVD-CHO (Ac-Asp-Glu-Val-Asp-aldehyde: inhibitor of CPP32 subfamily), taxotere-induced cell death was prevented. In addition, time course experiments demonstrated that activation of the ICE subfamily preceded activation of the CPP32 subfamily in taxotere-initiated death signaling, suggesting the direct involvement of the ICE cascade in taxotere-initiated death signaling. On the basis of these results, we suggest that taxotere causes the initiation of ICE cascade in its death signaling pathway and that the down-stream site of taxotere-initiated death signaling is the same as that of other chemotherapeutic agents. |
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Authors:
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A Suzuki; T Kawabata; M Kato |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 343 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-06-04 Completed Date: 1998-06-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 87-92 Citation Subset: IM |
Affiliation:
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Drug Safety Research Laboratory, Daiichi Pharmaceutical Co. Ltd., Tokyo R&D Center 16-13, Japan. LEB00373@niftyserve.or.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents, Phytogenic / pharmacology* Apoptosis / physiology* Caspase 1 Coloring Agents Cysteine Endopeptidases / physiology* L Cells (Cell Line) Mice Necrosis Paclitaxel / analogs & derivatives*, pharmacology Taxoids* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Coloring Agents; 0/Taxoids; 114977-28-5/docetaxel; 33069-62-4/Paclitaxel; EC 3.4.22.-/Cysteine Endopeptidases; EC 3.4.22.36/Caspase 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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