Document Detail

Necessity of formal genetic screening in artificial insemination by donor.
MedLine Citation:
PMID:  6888826     Owner:  NLM     Status:  MEDLINE    
After observing abnormal offspring following artificial insemination by donor, several authors recently have proposed intensive genetic screening of donors. The screening would be beyond that practiced by most infertility specialists. To determine the necessity for formal genetic investigation of donors, the authors analyzed the outcome of artificial insemination pregnancies in which donors were screened with careful medical and family histories, but were not subjected to formal pedigree analysis, karyotyping, or extensive metabolic screening. Fewer than 10% of potential donors were disqualified for genetic reasons. The study, limited to ascertaining the presence or absence of overt anomalies evident at birth, showed that such malformations were not more frequent in artificial insemination pregnancies (1.7%) than in controls (2.3%). It is concluded that extensive and formalized genetic screening is probably not necessary provided a thorough medical history is obtained. In addition, a practical approach to identifying donors at increased risk for siring abnormal offspring is offered.
M S Verp; M R Cohen; J L Simpson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  62     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-10-21     Completed Date:  1983-10-21     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  474-9     Citation Subset:  AIM; IM    
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MeSH Terms
Congenital Abnormalities / diagnosis,  epidemiology,  genetics
Genetic Diseases, Inborn / diagnosis*
Infant, Newborn
Insemination, Artificial*
Insemination, Artificial, Heterologous*
Grant Support

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