Document Detail


Necessity of formal genetic screening in artificial insemination by donor.
MedLine Citation:
PMID:  6888826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
After observing abnormal offspring following artificial insemination by donor, several authors recently have proposed intensive genetic screening of donors. The screening would be beyond that practiced by most infertility specialists. To determine the necessity for formal genetic investigation of donors, the authors analyzed the outcome of artificial insemination pregnancies in which donors were screened with careful medical and family histories, but were not subjected to formal pedigree analysis, karyotyping, or extensive metabolic screening. Fewer than 10% of potential donors were disqualified for genetic reasons. The study, limited to ascertaining the presence or absence of overt anomalies evident at birth, showed that such malformations were not more frequent in artificial insemination pregnancies (1.7%) than in controls (2.3%). It is concluded that extensive and formalized genetic screening is probably not necessary provided a thorough medical history is obtained. In addition, a practical approach to identifying donors at increased risk for siring abnormal offspring is offered.
Authors:
M S Verp; M R Cohen; J L Simpson
Related Documents :
9572446 - Second trimester maternal dimeric inhibin-a in the multiple-marker screening test for d...
11438946 - Between pregnancy biological variability of first trimester markers of down syndrome: i...
22977866 - Expression of carbohydrate metabolism markers in full-term spontaneous and induced preg...
24621206 - Urine nmr metabolomics analysis of breastfeeding biomarkers during and after pregnancy ...
8546646 - Sexuality in nigerian pregnant women: perceptions and practice.
20472606 - 'golden age' versus 'bad old days': a discursive examination of advice giving in antena...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  62     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-10-21     Completed Date:  1983-10-21     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  474-9     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Congenital Abnormalities / diagnosis,  epidemiology,  genetics
Female
Genetic Diseases, Inborn / diagnosis*
Humans
Infant, Newborn
Insemination, Artificial*
Insemination, Artificial, Heterologous*
Male
Pregnancy
Grant Support
ID/Acronym/Agency:
HD02841/HD/NICHD NIH HHS; HD11021/HD/NICHD NIH HHS; HD8-2855/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Plasma human chorionic gonadotropin disappearance in hydatidiform mole: a central registry report fr...
Next Document:  A case-control study of wound abscess after cesarean delivery.