| Necessity for Re-Vascularization after Spinal Cord Injury and the Search for Potential Therapeutic Options. | |
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MedLine Citation:
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PMID: 22023610 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Disruption of the blood-spinal cord barrier (BSCB) and microvascular changes leading to reduction of blood supply represent hallmarks of spinal cord secondary injury causing further deterioration of the traumatized patient. Injury to the blood vessels starts with prominent hemorrhage and generation of inflammation. Furthermore, spinal cord ischemia and extravasation of blood components contribute to edema formation resulting in death of neural cells. Endogenous attempts of re-vascularization have been observed although these newly formed vessels display morphological and functional abnormalities. The unfavorable regulation of angiogenic and counterregulatory anti-angiogenic factors during the complicated course of vessel remodeling after SCI is suspected to participate in the failure of re-vascularization and vessel stabilization. Repression of the expression of angiogenic factors such as vascular endothelial growth factor-A (VEGF-A), placental growth factor (PlGF), angiopoietin-1 (Ang1), and platelet-derived growth factor-BB (PDGF-BB) contributes to vessel regression. Therefore, therapeutic applications of angiogenic factors following SCI are promising strategies to restore blood flow in the lesion. |
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Authors:
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Ursula Graumann1; Marie-Françoise Ritz; Oliver Hausmann |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-21 |
Journal Detail:
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Title: Current neurovascular research Volume: - ISSN: 1875-5739 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101208439 Medline TA: Curr Neurovasc Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Biomedicine Brain Tumor Biology Laboratory Pharmacenter Klingelbergstrasse 50 4056 Basel, Switzerland. marie-francoise. ritz@unibas.ch. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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