Document Detail

Nebulized opioids use in COPD.
MedLine Citation:
PMID:  14769753     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the role of nebulized opioids in COPD. METHODS: A MEDLINE search was completed to obtain pertinent clinical literature. Key search terms included the following: nebulizer, opioids, COPD, dyspnea, morphine, and hydromorphone. RESULTS: Currently, the evidence in the literature is lacking regarding placebo-controlled studies to support nebulized morphine for the relief of dyspnea in patients with COPD. The studies reviewed varied considerably in the dose, opioid used, administration schedule, and methodology. One study found improved exercise capacity in 11 patients not reproducible in a larger sample, and another study found benefit in 54 terminal patients. All other studies found no benefit. CONCLUSIONS: The recently published Global Initiative for Lung Disease guidelines have specifically stated that opioids are contraindicated in COPD management due to the potential respiratory depression and worsening hypercapnia. Nebulized opioids should be discouraged, as current data do not support their use.
Pamela A Foral; Mark A Malesker; Guillermo Huerta; Daniel E Hilleman
Related Documents :
22131713 - Clinical observation on greeva stambha (cervical spondylosis) chikitsa.
10741103 - Systemic corticosteroids for chronic obstructive pulmonary disease: benefits and risks.
16712803 - Involvement of na(+), k(+)-atpase and endogenous digitalis-like compounds in depressive...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Chest     Volume:  125     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-10     Completed Date:  2004-03-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  691-4     Citation Subset:  AIM; IM    
Creighton University School of Pharmacy and Health Professions, 2500 California Plaza, Omaha, NE 68178, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Inhalation
Dose-Response Relationship, Drug
Drug Administration Schedule
Follow-Up Studies
Middle Aged
Narcotics / therapeutic use*
Nebulizers and Vaporizers*
Pulmonary Disease, Chronic Obstructive / diagnosis,  drug therapy*
Pulmonary Gas Exchange
Randomized Controlled Trials as Topic
Respiratory Function Tests
Risk Assessment
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
Comment In:
Chest. 2004 Feb;125(2):363-5   [PMID:  14769709 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Respiratory sinus arrhythmia: why does the heartbeat synchronize with respiratory rhythm?
Next Document:  Integrated health system for chronic disease management: lessons learned from France.