Document Detail


Nebulized amphotericin B combined with intravenous amphotericin B in rats with severe invasive pulmonary aspergillosis.
MedLine Citation:
PMID:  16641459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nebulized amphotericin B (AMB) combined with intravenous AMB was studied in persistently leukopenic rats with invasive pulmonary aspergillosis. Pulmonary concentrations of AMB after aerosol treatment were substantially higher than after intravenous liposomal AMB. Nebulized liposomal AMB in addition to intravenous AMB resulted in significantly prolonged survival compared to controls.
Authors:
Elisabeth J Ruijgrok; Marcel H A M Fens; Irma A J M Bakker-Woudenberg; Els W M van Etten; Arnold G Vulto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  50     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-27     Completed Date:  2006-06-09     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1852-4     Citation Subset:  IM    
Affiliation:
Department of Clinical Pharmacy, Medical Center Rijnmond-Zuid, Olympiaweg 350, 3078 HT Rotterdam, The Netherlands. e.j.ruijgrok@hetnet.nl
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MeSH Terms
Descriptor/Qualifier:
Amphotericin B / administration & dosage*,  pharmacology
Animals
Antifungal Agents / administration & dosage*,  pharmacology
Aspergillosis / drug therapy*
Aspergillus fumigatus / drug effects*
Biological Markers / metabolism
Injections, Intravenous
Liposomes
Lung Diseases, Fungal / drug therapy*,  microbiology
Nebulizers and Vaporizers / microbiology
Rats
Severity of Illness Index
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Biological Markers; 0/Liposomes; 1397-89-3/Amphotericin B
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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