| Nebulized albuterol for acute hyperkalemia in patients on hemodialysis. | |
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MedLine Citation:
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PMID: 2919849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY OBJECTIVE: To determine the efficacy and safety of nebulized albuterol in the acute treatment of hyperkalemia in patients on chronic hemodialysis. DESIGN: Prospective, double-blind, and placebo-controlled study. SETTING: Outpatient hemodialysis clinic at a university medical center. PATIENTS: Ten patients on maintenance hemodialysis who had chronic hyperkalemia. INTERVENTIONS: Patients received nebulized albuterol therapy (10 mg or 20 mg) or placebo (saline) on three separate occasions, serial measurements of plasma potassium levels, blood pressure, and pulse were then taken for a 2-hour period. MEASUREMENTS AND MAIN RESULT: Patients had a significant decrease in plasma potassium concentrations that was evident by 30 minutes and sustained for at least 2 hours after albuterol treatment. After the administration of 10- and 20-mg doses of albuterol, the maximal decrease in the plasma potassium levels was 0.62 +/- 0.09 and 0.98 +/- 0.14 mmol/L (SE), respectively. Nebulized saline administration did not produce a significant change in the plasma potassium concentrations. Patients did not develop symptoms or significant changes in blood pressure or heart rate with albuterol treatment. CONCLUSIONS: In the doses used, nebulized albuterol therapy resulted in a prompt and significant decrease in the plasma potassium concentrations in patients on hemodialysis, and caused no adverse cardiovascular effects. This treatment should be considered as an important adjunct for acute treatment of serious hyperkalemia in this population of patients. |
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Authors:
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M Allon; R Dunlay; C Copkney |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Annals of internal medicine Volume: 110 ISSN: 0003-4819 ISO Abbreviation: Ann. Intern. Med. Publication Date: 1989 Mar |
Date Detail:
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Created Date: 1989-03-29 Completed Date: 1989-03-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 426-9 Citation Subset: AIM; IM |
Affiliation:
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University of Oklahoma School of Medicine, Oklahoma City. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aerosols Aged Albuterol / administration & dosage, adverse effects, therapeutic use* Blood Pressure / drug effects Double-Blind Method Drug Evaluation Drug Resistance Heart Rate / drug effects Humans Hyperkalemia / drug therapy* Middle Aged Prospective Studies Renal Dialysis* |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 18559-94-9/Albuterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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