Document Detail

Nebivolol improves coronary flow reserve in patients with idiopathic dilated cardiomyopathy.
MedLine Citation:
PMID:  17065184     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Impaired coronary flow reserve (CFR) is a significant predictor of poor prognosis in patients with idiopathic dilated cardiomyopathy (IDC). Nebivolol reduces mortality and morbidity in patients with heart failure and left ventricular dysfunction, including cases caused by IDC. OBJECTIVE: To assess the effects of nebivolol on CFR in patients with IDC. METHODS: CFR was measured in 21 clinically stable patients with IDC (mean (SD) ejection fraction 35.7 (6.2)) at baseline and after 1 month of treatment with nebivolol once daily. A control group of apparently healthy subjects who were matched for age and sex was used for comparison. Resting and hyperaemic coronary flows were measured using transthoracic second-harmonic Doppler echocardiography. None of the subjects had any systemic disease. RESULTS: After 1 month of treatment, heart rate was reduced significantly (p<0.001). The blood pressure was decreased significantly (p<0.001). The left ventricular end-diastolic diameter and stroke volume were not changed significantly, but end-systolic diameter was decreased significantly (p<0.05). Resting rate-pressure product was lower after treatment with nebivolol, but dipyridamole-induced change was not influenced by the treatment. Nebivolol treatment reduced significantly coronary velocities at rest (p<0.02) and also caused a significant increase in coronary velocities after dipyridamole (p<0.02), leading to a greater CFR (2.02 (0.35) vs 2.61 (0.43), p<0.001). Nebivolol induced an absolute increase of 6% in the CFR in 17 of 21 patients (80.9%). CONCLUSIONS: In patients with IDC, 1 month of treatment with nebivolol induces a marked increase in CFR.
Dogan Erdogan; Hakan Gullu; Mustafa Caliskan; Ozgur Ciftci; Semra Baycan; Aylin Yildirir; Haldun Muderrisoglu
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Publication Detail:
Type:  Journal Article     Date:  2006-10-25
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  93     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-26     Completed Date:  2007-04-17     Revised Date:  2010-09-15    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  319-24     Citation Subset:  AIM; IM    
Cardiology Department, Konya Teaching and Medical Research Center, Baskent University, Konya, Turkey.
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MeSH Terms
Benzopyrans / administration & dosage*
Cardiomyopathy, Dilated / drug therapy*,  physiopathology,  ultrasonography
Case-Control Studies
Coronary Circulation / drug effects*
Dose-Response Relationship, Drug
Echocardiography, Doppler, Color
Ethanolamines / administration & dosage*
Middle Aged
Treatment Outcome
Vasodilator Agents / administration & dosage*
Reg. No./Substance:
0/Benzopyrans; 0/Ethanolamines; 0/Vasodilator Agents; 99200-09-6/nebivolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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