Document Detail

Nebcin in the treatment of experimental Pseudomonas keratitis.
MedLine Citation:
PMID:  814918     Owner:  NLM     Status:  MEDLINE    
When the ocular toxicity and the in vivo and in vitro effects of gentamicin, Nebcin, and saline solution were compared in experimentally induced Pseudomonas keratitis in rabbits, both antibiotics showed the same toxicity for the rabbits' conjunctival tissues. But Nebcin showed better in vitro and in vivo results than gentamicin, and the clinical effect was confirmed by culture study: significant numbers of organisms were recovered from the corneas of the gentamicin-treated rabbits but none from the corneas of the Nebcin-treated rabbits.
R Belfort; G Smolin; M Okumoto; H B Kim
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  59     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  1975 Dec 
Date Detail:
Created Date:  1976-05-25     Completed Date:  1976-05-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  725-9     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Clinical Trials as Topic
Gentamicins / therapeutic use,  toxicity
Keratitis / drug therapy*
Pseudomonas Infections / drug therapy*
Pseudomonas aeruginosa / drug effects
Tobramycin / pharmacology,  therapeutic use*,  toxicity
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Gentamicins; 32986-56-4/Tobramycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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