Document Detail

Near-total parathyroidectomy is beneficial for patients with secondary and tertiary hyperparathyroidism.
MedLine Citation:
PMID:  15657584     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Despite several options for the extent of parathyroidectomy in secondary and tertiary hyperparathyroidism, <5% of patients are referred for surgical procedures. The purpose of this study was to identify beneficial outcomes of near-total parathyroidectomy (NTPTX) in this population. METHODS: NTPTX (a vascularized parathyroid remnant is left in situ, and cryopreservation is performed) was completed in 142 patients with secondary (n = 93 patients) and tertiary (n = 49 patients) hyperparathyroidism, and was guided by intraoperative intact PTH (IOPTH). RESULTS: One hundred thirty-six of 142 patients (96%) remain cured at a mean follow-up time of 23 +/- 26 months. Six patients had missed mediastinal (n = 4 patients) or cervical (n = 2 patients) parathyroid glands. No patient required re-resection of a cervical parathyroid remnant. One patient had hypoparathyroidism and underwent autografting with cryopreserved tissue. NTPTX reduced parathyroid mass (4526 +/- 4515 mg to 77 +/- 56 mg) and IOPTH (1171 +/- 1252 pg/mL to 101 +/- 127 pg/mL). Fatigue and musculoskeletal pain resolved promptly after operation. Patients with tertiary hyperparathyroidism experienced an improvement in bone density of 3.6% per year. NTPTX achieved full healing of extremity ulcers without amputations or perioperative death in 22 patients with calciphylaxis. CONCLUSIONS: NTPTX effectively treats secondary and tertiary hyperparathyroidism in >95% patients. IOPTH monitoring and cryopreservation are valuable procedural adjuncts. Limb salvage in calciphylaxis, symptomatic relief, and improved bone density are substantial benefits to recommend this procedure to patients with renal hyperparathyroidism.
Mira Milas; Collin J Weber
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery     Volume:  136     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-01-19     Completed Date:  2005-03-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1252-60     Citation Subset:  AIM; IM    
Departmnt of General Surgery, Cleveland Clinic Foundation, 9500 Euclid Avenue/A80, Cleveland, OH 44195, USA.
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MeSH Terms
Hyperparathyroidism / blood,  diagnosis,  surgery*
Middle Aged
Parathyroid Hormone / blood
Parathyroidectomy / methods*
Treatment Outcome
Reg. No./Substance:
0/Parathyroid Hormone

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