| Near-infrared spectroscopy monitoring of cerebral oxygen during assisted ventilation. | |
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MedLine Citation:
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PMID: 21697979 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Changes in the arterial partial pressure of CO(2) (PaCO(2)) has a direct though transient effect on the cerebral vasculature and cerebral circulation. Decreased PaCO(2) levels lead to vasoconstriction and can result in dangerously low levels of cerebral perfusion that resolve in 4-6 h. It is currently believed that perfusion abnormalities contribute to intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL) in the neonate. PaCO(2)-induced vasoconstriction may contribute to the pathology of IVH and PVL. METHODS: Near-infrared spectroscopy [NIRS; (INVOS cerebral/somatic oximeter; Somanetics Corporation, Troy, MI, USA)] was utilized to determine changes in regional oxygenation (rSO(2)) of the brain in response to changes in ventilation in isoflurane anesthetized newborn piglets. RESULTS: Changes in cerebral rSO(2) correlated significantly with end-tidal CO(2) levels and to blood flow in the common carotid artery. This correlation was significant during baseline conditions, after periods of CO(2) loading and during periods of hypothermia. CONCLUSIONS: The results of the study demonstrate the utility of NIRS to accurately reflect changes in cerebral oxygenation and flow to the brain in response to changes in CO(2) levels in anesthetized, ventilated neonatal piglets. The use of NIRS may provide an early alert of low levels of cerebral blood flow and brain oxygenation, potentially helping in preventing the progression of IVH or PVL in the neonate. |
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Authors:
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Erin A Booth; Christopher Dukatz; Beena G Sood; Michael Wider |
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Publication Detail:
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Type: Journal Article Date: 2011-05-28 |
Journal Detail:
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Title: Surgical neurology international Volume: 2 ISSN: 2152-7806 ISO Abbreviation: Surg Neurol Int Publication Date: 2011 |
Date Detail:
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Created Date: 2011-06-23 Completed Date: 2011-07-14 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 101535836 Medline TA: Surg Neurol Int Country: India |
Other Details:
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Languages: eng Pagination: 65 Citation Subset: - |
Affiliation:
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Department of Medical Science, Somanetics Corporation, Troy, MI, USA. |
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