Document Detail

Near-infrared spectroscopy measure of limb peripheral perfusion in neonatal arterial thromboembolic disease.
MedLine Citation:
PMID:  23108325     Owner:  NLM     Status:  In-Data-Review    
AIM: In critically ill neonates, peripheral perfusion and oxygenation assessment may provide indirect information on circulatory failure in limb arterial thromboembolic emergencies. Aims of our study were: 1) to evaluate the changes on tissue oxygenation index, oxyhemoglobin, deoxyhemoglobin and blood volume obtained by near-infrared spectroscopy (NIRS) on the infants legs; 2) to compare them with ultrasonographic data.
METHODS: Tissue oxygenation index (TOI), oxyhemoglobin (O2Hb), deoxyhemoglobin (HHb) and blood volume (BV) differences were assessed by NIRS on the calf of 8 newborn infants (median weight 1995, range 585-3010 g; median gestational age 32.5, range 26-40 wks). An ultrasonographic scan of the arterial system was performed before the NIRS measurements, to validate the site of arterial occlusion.
RESULTS: A t-test for independent samples showed lower values in the affected limb for all NIRS measurements. TOI measurements displayed lower values in the thromboembolic limb (mean 44.79±12%) versus unaffected (mean 47.95±17.08%) (P=0.0001). Mean (SD) peak systolic velocity in the patent artery below the occlusion decreased from 108±25 cm/s in the normal limb to 25.6±28 cm/s in the thrombus site (P=0.02).
CONCLUSION: In neonatal intensive care units, measurement of limb peripheral perfusion and oxygenation seems to be clinically useful in arterial thromboembolic emergencies.
A Milan; F Freato; V Vanzo; G Camporese; M Baraldi; L Chiandetti; P Zaramella
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Minerva pediatrica     Volume:  64     ISSN:  0026-4946     ISO Abbreviation:  Minerva Pediatr.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-10-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400740     Medline TA:  Minerva Pediatr     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  633-9     Citation Subset:  IM    
Neonatal Intensive Care Unit, Department of Women and Children's Health, University of Padua, Padua, Italy -
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