Document Detail


Near infrared spectroscopy as possible non-invasive monitor of slow vasogenic ICP waves.
MedLine Citation:
PMID:  22327689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We aimed to study synchronisation between ICP and near infrared spectroscopy (NIRS) variables induced by vasogenic waves of ICP during an infusion study in hydrocephalic patients and after TBI. Nineteen patients presenting with hydrocephalus underwent a diagnostic intraventricular constant-flow infusion test. The original concept of the methodology, presented in the current paper, was derived from this material. Then the method was applied in 40 TBI patients, with results reported in an observational manner. During monitoring, NIRS deoxygenated and oxygenated haemoglobin (Hb, HbO(2)) were recorded simultaneously with ICP. Moving correlation coefficient (6 min) between Hb and HbO(2) was tested as a marker of the slow vasogenic waves of ICP.During infusion studies ICP increased from 10.7 (5.1) mmHg to a plateau of 18.9 (7.6) mmHg, which was associated with an increase in the power of slow ICP waves (p = 0.000017). Fluctuations of Hb and HbO(2) at baseline negatively correlated with each other, but switched to high positive values during periods of increased ICP slow-wave activity during infusion (p < 0.001). Similar behaviour was observed in TBI patients: baseline negative Hb/HbO(2) correlation changed to positive values during peaks of ICP of vasogenic nature.Correlating changes in Hb and HbO(2) may be of use as a method of non-invasive detection of vasogenic ICP waves.
Authors:
Ruwan Alwis Weerakkody; Marek Czosnyka; Christian Zweifel; Gianluca Castellani; Peter Smielewski; Ken Brady; John D Pickard; Zofia Czosnyka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurochirurgica. Supplement     Volume:  114     ISSN:  0065-1419     ISO Abbreviation:  Acta Neurochir. Suppl.     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-13     Completed Date:  2012-05-01     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  100962752     Medline TA:  Acta Neurochir Suppl     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  181-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Brain Injuries / metabolism
Hemoglobins / metabolism*
Humans
Intracranial Pressure / physiology*
Middle Aged
Monitoring, Physiologic / instrumentation*,  methods
Spectroscopy, Near-Infrared*
Statistics as Topic
Young Adult
Grant Support
ID/Acronym/Agency:
G0600986//Medical Research Council; G9439390//Medical Research Council
Chemical
Reg. No./Substance:
0/Hemoglobins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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