| Near-infrared fluorescent labeled peptosome for application to cancer imaging. | |
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MedLine Citation:
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PMID: 18163535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nonionic amphiphilic copolypeptides, which were composed of hydrophilic poly(sarcosine) and hydrophobic poly(gamma-methyl L-glutamate) blocks, were synthesized with varying chain lengths of the blocks. The polypeptides having a suitable hydrophilic and hydrophobic balance were found to form vesicular assemblies of 100 nm size in buffer, which was evidenced by the TEM observation, the DLS analysis, and the encapsulation experiment. The genuine peptide vesicles, peptosomes, were labeled with a near-infrared fluorescence (NIRF) probe. In vivo retention in blood experiment showed long circulation of the peptosome in rat blood as stable as the PEGylated liposome. NIRF imaging of a small cancer on mouse by using the peptosome as a nanocarrier was successful due to the EPR effect of the peptosome. Peptosome is shown here as a novel excellent nanocarrier for molecular imaging. |
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Authors:
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Hiroki Tanisaka; Shinae Kizaka-Kondoh; Akira Makino; Shotaro Tanaka; Masahiro Hiraoka; Shunsaku Kimura |
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Publication Detail:
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Type: Journal Article Date: 2007-12-29 |
Journal Detail:
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Title: Bioconjugate chemistry Volume: 19 ISSN: 1043-1802 ISO Abbreviation: Bioconjug. Chem. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-17 Completed Date: 2008-04-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010319 Medline TA: Bioconjug Chem Country: United States |
Other Details:
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Languages: eng Pagination: 109-17 Citation Subset: IM |
Affiliation:
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Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto-Daigaku-Katsura, Nishikyo-ku, Kyoto 615-8510, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Circular Dichroism Drug Carriers / metabolism Fluorescein-5-isothiocyanate / chemistry Fluorescent Dyes / analysis*, chemistry Infrared Rays* Male Mice Micelles Nanostructures / chemistry Neoplasms / metabolism* Peptides / analysis*, chemistry Permeability Polyglutamic Acid / analogs & derivatives, chemistry Rats Sarcosine / analogs & derivatives, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Fluorescent Dyes; 0/Micelles; 0/Peptides; 107-97-1/Sarcosine; 25086-16-2/poly-gamma-methylglutamate; 25513-46-6/Polyglutamic Acid; 25951-24-0/polysarcosine; 3326-32-7/Fluorescein-5-isothiocyanate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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