Document Detail

Near-haploid karyotype in a squamous cell lung carcinoma.
MedLine Citation:
PMID:  7692946     Owner:  NLM     Status:  MEDLINE    
Cytogenetic analysis of a squamous cell lung carcinoma revealed a near-haploid karyotype with 27 chromosomes, in both primary cultures and an established cell line. The only chromosomes with two homologs present were chromosomes X, 5, 7, and 22. The two X chromosomes were early and late replicating, respectively. No structural rearrangements could be detected. In vitro, the clone evolved by duplication towards hyperdiploidy with 54 chromosomes.
V Drouin; F Viguié; B Debesse
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Genes, chromosomes & cancer     Volume:  7     ISSN:  1045-2257     ISO Abbreviation:  Genes Chromosomes Cancer     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-12-07     Completed Date:  1993-12-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9007329     Medline TA:  Genes Chromosomes Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  209-12     Citation Subset:  IM    
Laboratoire de Biologie de la Fertilité et de Cytogénétique, Hôtel-Dieu, Hôpital Laennec, Paris, France.
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MeSH Terms
Carcinoma, Squamous Cell / genetics*
Chromosome Banding
Lung Neoplasms / genetics*
Middle Aged
Tumor Cells, Cultured

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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