Document Detail


Near-fatal methemoglobinemia after recreational inhalation of amyl nitrite aerosolized with a compressed gas blower.
MedLine Citation:
PMID:  16496068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adverse effects associated with recreational inhalation of nitrites are usually mild and rarely life-threatening. We report a rare case of near-fatal methemoglobinemia after inhalation of amyl nitrite after aerosolizing the liquid using a compressed gas blower designed to clean photographic equipment that employed hydrofluoroalkane-134a as a propellant. A 31-year-old previously healthy male became dyspneic and fainted soon after the recreational inhalation of amyl nitrite aerosolized using a compressed gas blower. He was brought to the emergency department with severe cyanotic appearance and profound shock. Oxygen saturation was 82%, unresponsive to oxygen supply. His methemoglobin blood level was 52.2%. After 100 mg of methylene blue (2 mg/kg body weight) was administered intravenously, he recovered consciousness, and dyspnea and cyanosis subsided gradually. This case illustrates the extraordinary hazard of the use of a compressed gas blower in the recreational inhalation of nitrites. Prompt recognition and rapid antidotal treatment may adequately correct near-fatal overdose associated with recreational use of amyl nitrite.
Authors:
Chih-Hao Lin; Cheng-Chung Fang; Chien-Chang Lee; Patrick Chow-In Ko; Wen-Jone Chen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the Formosan Medical Association = Taiwan yi zhi     Volume:  104     ISSN:  0929-6646     ISO Abbreviation:  J. Formos. Med. Assoc.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2006-02-23     Completed Date:  2006-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214933     Medline TA:  J Formos Med Assoc     Country:  China    
Other Details:
Languages:  eng     Pagination:  856-9     Citation Subset:  IM    
Affiliation:
Department of Emergency Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aerosols
Amyl Nitrite / poisoning*
Humans
Male
Methemoglobinemia / chemically induced*,  drug therapy
Methylene Blue / therapeutic use
Street Drugs / poisoning*
Chemical
Reg. No./Substance:
0/Aerosols; 0/Street Drugs; 61-73-4/Methylene Blue; 8017-89-8/Amyl Nitrite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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