Document Detail


MedLine Citation:
PMID:  11932007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The inability of current technology to determine contiguous sequence for highly repetitive regions means that centromeres fall within multi-megabase gaps, analogous to black holes from which no information escapes. However, high-resolution mapping of a human X-centromere border reveals a remarkable structure, including a gradient of alpha-satellite divergence up to the edge of the youngest and most homogeneous repeats.
Authors:
Steven Henikoff
Related Documents :
2475307 - Visualization of centromere proteins cenp-b and cenp-c on a stable dicentric chromosome...
565337 - Centromere inactivation in a case of turner variant with two dicentric iso-long arm y c...
20029167 - First case of a neocentromere formation in an otherwise normal chromosome 7.
8187547 - Segmental tetrasomy of chromosome 12 in the mouse.
9067427 - Complex chromosomal mechanisms lead to aprt loss of heterozygosity in heteroploid cells.
25264457 - Smoking-induced chromosomal segregation anomalies identified by fish analysis of sperm.
Publication Detail:
Type:  News    
Journal Detail:
Title:  Trends in genetics : TIG     Volume:  18     ISSN:  0168-9525     ISO Abbreviation:  Trends Genet.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-04     Completed Date:  2002-10-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8507085     Medline TA:  Trends Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  165-7     Citation Subset:  IM    
Affiliation:
Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. steveh@fhcrc.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Centromere*
DNA Transposable Elements
DNA, Satellite / genetics
Euchromatin / genetics
Evolution, Molecular
Heterochromatin
Humans
Repetitive Sequences, Nucleic Acid
Sequence Analysis, DNA
X Chromosome*
Chemical
Reg. No./Substance:
0/DNA Transposable Elements; 0/DNA, Satellite; 0/Euchromatin; 0/Heterochromatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Heat shock protein Hsp70 expression and DNA damage in Baikalian sponges exposed to model pollutants ...
Next Document:  New alleles of Notch draw a blueprint for multifunctionality.