Document Detail

Nd: YAG interstitial laser phototherapy guided by magnetic resonance imaging in an ex vivo model: dosimetry of laser-MR-tissue interaction.
MedLine Citation:
PMID:  2062157     Owner:  NLM     Status:  MEDLINE    
Interstitial laser phototherapy (ILP) is a promising technique in which laser energy is delivered percutaneously to various depths of tumors. This technique will become clinically useful only when efficient, sensitive, and noninvasive monitoring systems are developed. In this study, the spatial distribution of ILP in bovine liver tissue, induced by a Nd: YAG laser with an interstitial sapphire-frosted contact probe, was evaluated by magnetic resonance imaging (MRI). Tissue was exposed to three energy densities of the Nd:YAG laser by a reproducible method of dosimetry. Thermal profiles were measured with a probe inserted 5 mm from the laser tip. T1-weighted magnetic resonance images were taken after the laser exposure. Tissue specimens were then evaluated for standard quantification of laser-induced damages. A linear correlation between the level of laser energy, induced temperature change, lesion size on T1 magnetic resonance image, and volume of histological damage was observed. Further improvement of this technique of dosimetry in an in vivo model should allow the development of software for MRI which will correlate the above parameters and render this technique of ILP clinically useful.
Y Anzai; R B Lufkin; R E Saxton; H Fetterman; K Farahani; L J Layfield; F C Jolesz; W H Hanafee; D J Castro
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Laryngoscope     Volume:  101     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-08-08     Completed Date:  1991-08-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  755-60     Citation Subset:  IM    
Department of Radiological Sciences, UCLA School of Medicine 90024-1624.
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MeSH Terms
Laser Therapy*
Liver / radiation effects*
Magnetic Resonance Imaging*
Phototherapy / methods*
Radiation Dosage
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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