Document Detail

Navigational error in the heart leads to premature ventricular excitation.
MedLine Citation:
PMID:  21266771     Owner:  NLM     Status:  MEDLINE    
In the normal heart, an insulating barrier separates the atria and ventricles. The only way in which electrical impulses can cross this barrier is via the atrioventricular (AV) node, which delays impulse conduction to ensure the forward flow of the blood. However, in some individuals, additional muscular bundles (accessory pathways) allow rapid conduction of electrical impulses from the atria to the ventricles, resulting in premature ventricular excitation and contraction. In this issue of the JCI, two independent research groups demonstrate that erroneous development of the embryonic AV canal, which performs a similar function to that of the adult AV node, is a novel mechanism by which accessory pathways can form.
Hiroshi Akazawa; Issei Komuro
Publication Detail:
Type:  Comment; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-01-25
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  121     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-02     Completed Date:  2011-03-28     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  513-6     Citation Subset:  AIM; IM    
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
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MeSH Terms
Accessory Atrioventricular Bundle / embryology*,  physiopathology*
Atrioventricular Node / embryology*,  physiopathology*
Heart Conduction System / embryology*,  physiopathology*
Heart Ventricles / physiopathology*
Wolff-Parkinson-White Syndrome
Comment On:
J Clin Invest. 2011 Feb;121(2):534-44   [PMID:  21266775 ]
J Clin Invest. 2011 Feb;121(2):525-33   [PMID:  21266778 ]

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