| Navigational error in the heart leads to premature ventricular excitation. | |
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MedLine Citation:
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PMID: 21266771 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the normal heart, an insulating barrier separates the atria and ventricles. The only way in which electrical impulses can cross this barrier is via the atrioventricular (AV) node, which delays impulse conduction to ensure the forward flow of the blood. However, in some individuals, additional muscular bundles (accessory pathways) allow rapid conduction of electrical impulses from the atria to the ventricles, resulting in premature ventricular excitation and contraction. In this issue of the JCI, two independent research groups demonstrate that erroneous development of the embryonic AV canal, which performs a similar function to that of the adult AV node, is a novel mechanism by which accessory pathways can form. |
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Authors:
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Hiroshi Akazawa; Issei Komuro |
Publication Detail:
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Type: Comment; Journal Article; Research Support, Non-U.S. Gov't Date: 2011-01-25 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 121 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-02 Completed Date: 2011-03-28 Revised Date: 2012-02-07 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 513-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Accessory Atrioventricular Bundle
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embryology*,
physiopathology* Adult Animals Atrioventricular Node / embryology*, physiopathology* Heart Conduction System / embryology*, physiopathology* Heart Ventricles / physiopathology* Humans Mice Wolff-Parkinson-White Syndrome |
| Comments/Corrections | |
Comment On:
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J Clin Invest. 2011 Feb;121(2):534-44
[PMID:
21266775
]
J Clin Invest. 2011 Feb;121(2):525-33 [PMID: 21266778 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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