Document Detail

Nav Channel Complex Heterogeneity: New Targets for the Treatment of Arrhythmia?
MedLine Citation:
PMID:  24895456     Owner:  NLM     Status:  Publisher    
Despite major breakthroughs in cardiovascular diagnostics and therapies over the past century, diseases of the heart remain the number one cause of death in the United States, nearing 600,000 deaths per year.(1) Most of these deaths (200,000-400,000/year(2)) are due to cardiac arrhythmia where syncope and sudden death are often the first manifestations of heart disease. Foundational work of Keating and colleagues in the mid-1990's cemented the critical role of ion channel dysfunction in human arrhythmia.(3) Today, we now know that ~35% of sudden unexplained death and ~20% of sudden infant death syndrome cases may be explained by mutations in cardiac ion channels ("cardiac channelopathies").(4, 5) Further, defects in ion channel function have widely been observed in common forms of heart failure.(6) This year marks the 25(th) anniversary of publication of the preliminary Cardiac Arrhythmia Suppression Trial (CAST) findings in New England Journal of Medicine.(7) Here, we discuss new findings from Abriel and colleagues on Nav channel macromolecular complexes reported in this issue of Circulation(8), and reflect on lessons learned in the ensuing years after CAST that may help propel advances in treatment of cardiovascular disease over the next quarter century.
Thomas J Hund; Peter J Mohler
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-3
Journal Detail:
Title:  Circulation     Volume:  -     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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