Document Detail

Nausea and vomiting associate with increasing maternal androgen levels in otherwise uncomplicated pregnancies.
MedLine Citation:
PMID:  12694117     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The objective of the present study was to investigate the hypothesis that maternal androgen levels associate with nausea and vomiting in otherwise uncomplicated pregnancies. METHODS: One hundred and twenty-nine women with uncomplicated pregnancies, reported nausea and vomiting in weeks 17, 25, 33, 37, and when admitted for delivery. Maternal levels of androstenedione, dehydroepiandrosterone sulfate (DHEAS), testosterone, and sex hormone binding globulin (SHBG) were measured and the free testosterone index calculated in weeks 17 and 33 of pregnancy. RESULTS: Maternal levels of androstenedione and DHEAS associated positively with nausea and vomiting in week 17. In week 33, testosterone and DHEAS associated positively with nausea and vomiting, as well as androstenedione. A calculated emesis score associated positively with increasing average levels of both androstenedione and testosterone during pregnancy, as well as the free testosterone index. CONCLUSIONS: Nausea and vomiting associate with increasing maternal androgen levels during otherwise uncomplicated pregnancies. Whether androgens are causally related to emesis gravidarum remains unknown.
Sven Magnus Carlsen; Eszter Vanky; Geir Jacobsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  82     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-04-15     Completed Date:  2003-05-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  225-8     Citation Subset:  IM    
Section of Endocrinology, Department of Medicine, St. Olavs. Hospital, University Hospital of Trondheim, Norway.
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MeSH Terms
Androgens / blood*
Androstenedione / blood
Dehydroepiandrosterone Sulfate / blood
Infant, Newborn
Nausea / blood*
Pregnancy Complications / blood*
Sex Hormone-Binding Globulin / metabolism
Testosterone / blood
Vomiting / blood*
Grant Support
Reg. No./Substance:
0/Androgens; 0/Sex Hormone-Binding Globulin; 58-22-0/Testosterone; 63-05-8/Androstenedione; 651-48-9/Dehydroepiandrosterone Sulfate

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