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ON THE NATURE OF THE PRESSOR ACTION OF RENIN.
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MedLine Citation:
PMID:  19870928     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
1. Tachyphylaxis occurs when renin is repeatedly injected into dogs and cats regardless of whether they are normal, anesthetized, pithed, hepatectomized, suprarenalectomized, nephrectomized, or eviscerated. 2. The pressor response to renin in brief experiments is independent of the height of the arterial pressure or the presence of the suprarenals. Evisceration and large doses of ergotamine reduce the response. It is largely uninfluenced by pithing, intracisternal injection of renin, cocaine, strychnine, caffeine, and infusion of sodium bicarbonate or hydrochloric acid. It may be slightly increased by large blood transfusions or hepatectomy but the result is short lived. 3. There is no parallelism between the pressor responses to carotid sinus stimulation, adrenine, and tyramine on the one hand and renin on the other. 4. Section of the brain may be followed by depressor responses to renin. 5. Intracisternal injection of renin elicits no significant rise in blood pressure or other circulatory manifestations. 6. Continuous infusion of renin produces a prolonged rise of arterial pressure in normal and chronically suprarenalectomized dogs, but the pressure ultimately falls despite continued infusion. 7. Tachyphylaxis develops in the isolated rabbit's ear perfused with blood and small doses of renin. The same blood perfused through a second ear causes no vasoconstriction when renin is added. Addition of renin-activator restores the ability of renin to cause constriction. 8. Renin alone causes no vasoconstriction when perfused with Ringer's solution, but renin plus renin-activator restores activity. Tachyphylaxis does not develop when Ringer's solution is employed instead of recirculating blood. 9. Blood from animals made tachyphylactic by repeated injections of renin is lacking in activator and also fails to cause vasoconstriction in the rabbit's ear when renin and renin-activator are added. 10. Renin-activator is lost and tachyphylaxis develops more slowly during continuous infusion of renin. Blood pressure may fall after a period of renin infusion despite the pressure in the blood of excess renin. Injection of partially purified activator restores the activator content of the blood as demonstrated in the rabbit's ear, but no rise in arterial pressure occurs.
Authors:
I H Page
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  70     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1939 Oct 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-06-23     Revised Date:  2010-09-28    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  521-42     Citation Subset:  -    
Affiliation:
Lilly Laboratory for Clinical Research, Indianapolis City Hospital, Indianapolis.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1939, by The Rockefeller Institute for Medical Research New York
Received Day: 6 Month: 8 Year: 1939
Print publication date: Day: 31 Month: 10 Year: 1939
Volume: 70 Issue: 5
First Page: 521 Last Page: 542
ID: 2133806
PubMed Id: 19870928

ON THE NATURE OF THE PRESSOR ACTION OF RENIN
Irvine H. Page
From the Lilly Laboratory for Clinical Research, Indianapolis City Hospital, Indianapolis


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