Document Detail


Nature and nurture in infant appetite: analysis of the Gemini twin birth cohort.
MedLine Citation:
PMID:  20335548     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A strong genetic influence on appetitive traits has been shown in children and adults, but no studies have examined appetite in early infancy, even though avidity of appetite has been linked with a higher risk of obesity.
OBJECTIVE: The objective was to investigate the heritability in early infancy of 4 appetitive traits that have been shown to be heritable later in childhood.
DESIGN: Data are from the Gemini Study, a population-based sample of twins (n = 2402 pairs) born in England and Wales in 2007. To describe their children's eating behavior during the first 3 mo of life while they were still exclusively milk fed, the parents of the twins completed 4 subscales of the Baby Eating Behavior Questionnaire: "enjoyment of food," "food responsiveness," "slowness in eating," and "satiety responsiveness." Heritability was estimated by using quantitative genetic model fitting.
RESULTS: Heritability was high for slowness in eating (84%; 95% CI: 83%, 86%) and satiety responsiveness (72%; 95% CI: 65%, 80%) and moderate for food responsiveness (59%; 95% CI: 52%, 65%) and enjoyment of food (53%; 95% CI: 43%, 63%).
CONCLUSIONS: Genetically determined variability in appetitive traits may be one of the pathways through which genes influence the growth rate in infancy. Early identification of infants with avid appetites may make it possible to implement strategies to attenuate the expression of these traits before excessive weight gain occurs.
Authors:
Clare H Llewellyn; Cornelia H M van Jaarsveld; Laura Johnson; Susan Carnell; Jane Wardle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Twin Study     Date:  2010-03-24
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  91     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-05-28     Revised Date:  2014-10-07    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1172-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Appetite / genetics*,  physiology*
Birth Weight
England
Environment
Family
Feeding Behavior / physiology*
Female
Genetic Variation
Gestational Age
Heterozygote
Homozygote
Humans
Infant
Male
Models, Genetic
Questionnaires
Satiety Response / physiology
Wales
Grant Support
ID/Acronym/Agency:
14133//Cancer Research UK; C1418/A7974//Cancer Research UK

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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