Document Detail


Nature of inducible ventricular tachyarrhythmias in a canine chronic myocardial infarction model.
MedLine Citation:
PMID:  6637836     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A canine model suitable for serial conscious studies was developed to evaluate the nature of sustained ventricular tachyarrhythmias in chronic experimental myocardial infarction. Thirteen dogs underwent left anterior descending coronary artery ligation followed by complete reperfusion; 11 sham-operated dogs served as controls. In this model, ventricular tachyarrhythmias are inducible in most dogs with experimental infarction and in several dogs without this condition. The morphologic features, rate and drug response of the induced arrhythmias are unlike those of human ventricular tachycardia. Tachyarrhythmia induction is facilitated by anesthesia and thoracotomy. This canine infarct model does not adequately imitate human recurrent ventricular tachycardia, but may simulate human sudden cardiac death.
Authors:
D S Echt; J C Griffin; A J Ford; J W Knutti; R C Feldman; J W Mason
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  52     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1127-32     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arrhythmias, Cardiac / etiology*
Cardiac Pacing, Artificial
Dogs
Electrophysiology
Heart Conduction System / physiopathology
Heart Ventricles
Myocardial Infarction / complications*
Pacemaker, Artificial
Recurrence
Tachycardia / etiology
Telemetry
Ventricular Fibrillation / etiology
Grant Support
ID/Acronym/Agency:
5-P50-GM17940/GM/NIGMS NIH HHS; 5T32 HL07265-03/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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