Document Detail

Naturally oncolytic viruses.
MedLine Citation:
PMID:  16955694     Owner:  NLM     Status:  MEDLINE    
Naturally oncolytic viruses are replication-competent viruses that have an innate ability to selectively infect and kill tumor cells. Despite being used in the original attempts to treat cancer with live viruses five decades ago, interest in naturally oncolytic viruses has lagged behind the support for engineered adenoviruses and herpesviruses as cancer therapeutics. Recently, however, there has been renewed interest in the high potency and selectivity of these naturally occurring agents. In this review, the mechanism of selectivity as well as the preclinical and clinical activity of naturally oncolytic viruses will be discussed.
M Scot Roberts; Robert M Lorence; William S Groene; Michael K Bamat
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in molecular therapeutics     Volume:  8     ISSN:  1464-8431     ISO Abbreviation:  Curr. Opin. Mol. Ther.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-09-06     Completed Date:  2006-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100891485     Medline TA:  Curr Opin Mol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  314-21     Citation Subset:  IM    
Wellstat Biologics Corp, 930 Clopper Road, Gaithersburg, MD 20878, USA.
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MeSH Terms
Antigens, CD46 / metabolism
Genetic Vectors
Neoplasms / pathology,  therapy*
Oncolytic Virotherapy*
Oncolytic Viruses* / genetics,  metabolism
Virus Replication
Reg. No./Substance:
0/Antigens, CD46

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