Document Detail

Naturally occurring toxic substances in foods.
MedLine Citation:
PMID:  334438     Owner:  NLM     Status:  MEDLINE    
Numerous chemical toxins, including normal components of natural foods, e.g., mycotoxins, and toxic chemicals as contaminants such as pesticides, fertilizers, food additives, and preservatives, which are potentially toxic to humans, are discussed. Potential toxicity, the hazard to man represented by most of these chemicals, may be low because the concentration in food may be low. The gap in our knowledge of long-term effects makes rational decisions as to allowable levels of these substances a major problem. On the other hand, nitrosamines and aflatoxins are toxins for which there exists a voluminous literature documentaing extreme biologic activity in experimental animals and indirect evidence for activity in man. Epidemiologic evidence has linked them to human cancers, and because of increasing evidence of long-term human exposure to these toxins either as inadvertent contaminants during food preparation or as the metabolites of mycotic infestation this possible hazard demands intensive investigation. An exhaustive review of data from epidemiologic surveys in various parts of the world, as well as from long-term laboratory studies, represents an impressive start in this direction.
R L Gross; P M Newberne
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  22     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1977 Nov 
Date Detail:
Created Date:  1977-12-29     Completed Date:  1977-12-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  680-98     Citation Subset:  AIM; IM    
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MeSH Terms
Aflatoxins / adverse effects
Drug-Induced Liver Injury / etiology
Food Analysis
Food Contamination*
Nitrosamines / adverse effects,  analysis,  metabolism
Plants, Edible / analysis
Protease Inhibitors
Toxins, Biological* / adverse effects,  analysis
Reg. No./Substance:
0/Aflatoxins; 0/Nitrosamines; 0/Protease Inhibitors; 0/Toxins, Biological

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