Document Detail


Naturally occurring hypertension in New World nonhuman primates: Potential role of the perifornical hypothalamus.
MedLine Citation:
PMID:  17023668     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertension is a prominent underlying factor in the genesis of cardiovascular-related morbidity and mortality. A major impediment to the investigation into the causes of the disease is the paucity of naturally occurring animal models of the disease. There is evidence that some species of New World primates spontaneously become hypertensive. We used chronically implanted pressure transducers to assess normally occurring blood pressure and heart rate levels at rest and during routine laboratory procedures in a group of one of these New World primates (Aotus sp.). Resting mean arterial pressure ranged from 72 to 130 mmHg. Three animals were judged to have resting mean arterial pressure levels in the hypertensive range (> or =110 mmHg). In all of the animals, pressor responses to routine laboratory events were exaggerated (average highest mean pressure during 1 min from any session was 97-196 mmHg). Subsequently, the region of the perifornical/lateral hypothalamus known to produce elevated blood pressure and heart rate responses to electrical stimulation was removed, and the blood pressure responses to the laboratory routines were significantly decreased and, in some cases, eliminated. Control lesions in nearby tissue had no effect on these responses. This region may play a critical role in initiating or exacerbating cardiovascular responses that contribute to the development of essential hypertension.
Authors:
Orville A Smith; Cliff A Astley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-10-05
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  292     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-02     Completed Date:  2007-03-08     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R937-45     Citation Subset:  IM    
Affiliation:
National Primate Research Center at the University of Washington, University of Washington, Seattle, Washington, USA. oas@u.washington.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Aotidae / physiology*
Blood Pressure / physiology
Electric Stimulation
Emotions / physiology
Female
Heart Rate / physiology
Hypertension / physiopathology*
Hypothalamic Area, Lateral / physiology
Hypothalamus / physiopathology*
Male
Neurons / physiology
Telemetry
Transducers
Grant Support
ID/Acronym/Agency:
HL-16910/HL/NHLBI NIH HHS; HL-50351/HL/NHLBI NIH HHS; RR-00166/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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