Document Detail

Naturally occurring antifungal agents against Zygosaccharomyces bailii and their synergism.
MedLine Citation:
PMID:  15969495     Owner:  NLM     Status:  MEDLINE    
Polygodial was found to exhibit a fungicidal activity against a food spoilage yeast, Zygosaccharomyces bailii, with the minimum fungicidal concentration (MFC) of 50 microg/mL (0.17 mM). The time-kill curve study showed that polygodial was fungicidal at any growth stage. The primary action of polygodial comes from its ability to disrupt the native membrane-associated function of integral proteins as nonionic surface active agents (surfactants) followed by a decrease in plasma membrane fluidity. The fungicidal activity of polygodial was increased 128-fold in combination with a sublethal amount (equivalent of 1/2 MFC) of anethole and vice versa relative to the fungicidal activity of anethole. The fungicidal activity of sorbic acid was enhanced 512-fold in combination with 1/2 MFC of polygodial. Conversely, the fungicidal activity of polygodial was enhanced 128-fold in combination with 1/2 MFC of sorbic acid.
Ken-Ichi Fujita; Isao Kubo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  53     ISSN:  0021-8561     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-22     Completed Date:  2005-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5187-91     Citation Subset:  IM    
Department of Environmental Science, Policy and Management, University of California, Berkeley, 94720-3112, USA.
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MeSH Terms
Anisoles / pharmacology
Cell Membrane / drug effects
Drug Synergism
Fungicides, Industrial / pharmacology*
Membrane Fluidity / drug effects
Polygonum / chemistry
Sesquiterpenes / pharmacology*
Sorbic Acid / pharmacology
Zygosaccharomyces / drug effects*,  growth & development
Reg. No./Substance:
0/Anisoles; 0/Fungicides, Industrial; 0/Sesquiterpenes; 104-46-1/anethole; 110-44-1/Sorbic Acid; 6754-20-7/polygodial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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