Document Detail


Naturally acquired microchimerism.
MedLine Citation:
PMID:  19924635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bi-directional transplacental trafficking occurs routinely during the course of normal pregnancy, from fetus to mother and from mother to fetus. In addition to a variety of cell-free substances, it is now well recognized that some cells are also exchanged. Microchimerism refers to a small number of cells (or DNA) harbored by one individual that originated in a genetically different individual. While microchimerism can be the result of iatrogenic interventions such as transplantation or transfusion, by far the most common source is naturally acquired microchimerism from maternal-fetal trafficking during pregnancy. Microchimerism is a subject of much current interest for a number of reasons. During pregnancy, fetal microchimerism can be sought from the mothers blood for the purpose of prenatal diagnosis. Moreover, studies of fetal microchimerism during pregnancy may offer insight into complications of pregnancy, such as preeclampsia, as well as insights into the pathogenesis of autoimmune diseases such as rheumatoid arthritis which usually ameliorates during pregnancy. Furthermore, it is now known that microchimerism persists decades later, both fetal microchimerism in women who have been pregnant and maternal microchimerism in her progeny. Investigation of the long-term consequences of fetal and maternal microchimerism is another exciting frontier of active study, with initial results pointing both to adverse and beneficial effects. This review will provide an overview of microchimerism during pregnancy and of current knowledge regarding long-term effects of naturally acquired fetal and maternal microchimerism.
Authors:
Hilary S Gammill; J Lee Nelson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The International journal of developmental biology     Volume:  54     ISSN:  1696-3547     ISO Abbreviation:  Int. J. Dev. Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-08     Completed Date:  2010-03-31     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  8917470     Medline TA:  Int J Dev Biol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  531-43     Citation Subset:  IM    
Affiliation:
Department of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA. hgammill@u.washington.edu
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MeSH Terms
Descriptor/Qualifier:
Autoimmune Diseases / genetics*
Chimerism*
DNA / genetics
Female
Humans
Maternal-Fetal Exchange / genetics*
Pregnancy
Time
Grant Support
ID/Acronym/Agency:
K12 HD001264-07/HD/NICHD NIH HHS; R01 AI041721-11/AI/NIAID NIH HHS; R01 AI045659-09/AI/NIAID NIH HHS; R03 AI045952-02/AI/NIAID NIH HHS; R21 AI072547-02/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
9007-49-2/DNA
Comments/Corrections

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