Document Detail


Natural variation in plasticity of glucose homeostasis and food intake.
MedLine Citation:
PMID:  18805815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Balancing the acquisition, allocation and storage of energy during periods of food deprivation is critical for survival. We show that natural variation in the foraging (for) gene, which encodes a cGMP-dependent protein kinase (PKG) in the fruit fly Drosophila melanogaster, affects behavioral and physiological responses to short-term food deprivation. Rover and sitter, natural allelic variants of for, differ in their stored carbohydrate reserves as well as their response to short-term deprivation. Fewer carbohydrates are stored in the fat body of rovers compared with sitters, and more labeled glucose is allocated to lipid stores compared with carbohydrate stores during a short feeding bout. Short-term food deprivation decreases hemolymph glucose levels in rovers but not in sitters. After food deprivation, rovers increase their food intake more slowly than sitters, and rover hemolymph levels take longer to respond to re-feeding. Finally, rovers have lower adipokinetic hormone (akh) mRNA levels than sitters. Our data suggest that for mediates larval responses to short-term food deprivation by altering food intake and blood glucose levels.
Authors:
Karla R Kaun; Munmun Chakaborty-Chatterjee; Marla B Sokolowski
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of experimental biology     Volume:  211     ISSN:  0022-0949     ISO Abbreviation:  J. Exp. Biol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-22     Completed Date:  2008-12-04     Revised Date:  2014-05-29    
Medline Journal Info:
Nlm Unique ID:  0243705     Medline TA:  J Exp Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  3160-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose
Cyclic GMP-Dependent Protein Kinases / genetics*,  physiology
Drosophila Proteins / genetics*,  physiology
Drosophila melanogaster / genetics,  metabolism,  physiology*
Eating / genetics
Feeding Behavior
Genetic Variation
Glucose / metabolism*
Hemolymph / metabolism
Homeostasis
Insect Hormones / genetics,  metabolism
Lipid Metabolism / genetics
Oligopeptides / genetics,  metabolism
Pyrrolidonecarboxylic Acid / analogs & derivatives,  metabolism
RNA, Messenger / metabolism
Grant Support
ID/Acronym/Agency:
5R01DK070141-03/DK/NIDDK NIH HHS; R01 DK070141/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Drosophila Proteins; 0/Insect Hormones; 0/Oligopeptides; 0/RNA, Messenger; 0/adipokinetic hormone; EC 2.7.11.12/Cyclic GMP-Dependent Protein Kinases; EC 2.7.11.12/foraging protein, Drosophila; IY9XDZ35W2/Glucose; SZB83O1W42/Pyrrolidonecarboxylic Acid
Comments/Corrections

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