Document Detail


Natural and synthetic regulators of embryonic stem cell cardiogenesis.
MedLine Citation:
PMID:  19319460     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Debilitating cardiomyocyte loss underlies the progression to heart failure. Although there have been significant advances in treatment, current therapies are intended to improve or preserve heart function rather than regenerate lost myocardium. A major hurdle in implementing a cell-based regenerative therapy is the inefficient differentiation of cardiomyocytes from either endogenous or exogenous stem cell sources. Moreover, cardiomyocytes that develop in human embryonic stem cell (hESC) or human-induced pluripotent stem cell (hIPSC) cultures are comparatively immature, even after prolonged culture, and differences in their calcium handling, ion channel, and force generation properties relative to adult cardiomyocytes raise concerns of improper integration and function after transplantation. Thus, the discovery of natural and novel small molecule synthetic regulators of differentiation and maturation would accelerate the development of stem-cell-based myocardial therapies. Here, we document recent advances in defining natural signaling pathways that direct the multistep cardiomyogenic differentiation program and the development of small molecules that might be used to enhance differentiation as well as the potential characteristics of lead candidates for pharmaceutical stimulation of endogenous myocardial replacement.
Authors:
Erik Willems; Paul J Bushway; Mark Mercola
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-03-25
Journal Detail:
Title:  Pediatric cardiology     Volume:  30     ISSN:  1432-1971     ISO Abbreviation:  Pediatr Cardiol     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-08     Completed Date:  2009-08-18     Revised Date:  2013-03-27    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  635-42     Citation Subset:  IM    
Affiliation:
Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
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MeSH Terms
Descriptor/Qualifier:
Cell Differentiation
Embryonic Stem Cells / physiology*
Heart / embryology*
Humans
Myocytes, Cardiac / physiology*
Regeneration / drug effects,  physiology*
Signal Transduction
Grant Support
ID/Acronym/Agency:
R33 HL088266/HL/NHLBI NIH HHS; R33HL088266/HL/NHLBI NIH HHS; R37 HL059502/HL/NHLBI NIH HHS; R37HL059502/HL/NHLBI NIH HHS
Comments/Corrections

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