Document Detail


Natural and subclinical Corynebacterium kutscheri infection in rats.
MedLine Citation:
PMID:  7752607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Distribution of Corynebacterium kutscheri was determined in 41 rats housed in a conventionally managed colony that were infected naturally and subclinically. At 2, 5, 10, 20 and 25 months after initial isolation of C. kutscheri, attempts were made to isolate C. kutscheri from 17 sites, with a new selective medium, FNC agar. In total, the prevalence (97.6%) of C. kutscheri isolation was significantly (P < 0.001) higher than the frequency (70.7%) of antibody detection. None of the rats manifested any distinct clinical signs of disease and macroscopic lesions caused by C. kutscheri were not detected. In 40 rats with subclinical infection, the organisms were most frequently isolated from the oral cavity, esophagus, cecal contents, and colon and rectum (> 95.0%). The isolation rate was next highest in the trachea, submaxillary lymph nodes, and nasal cavity (47.5 to 52.5%). The organisms hardly colonized the lung, liver, and kidney. Mean numbers of organisms found in the esophagus, cecal contents, and colon and rectum ranged from 10(3.9) to 10(4.2) CFU/g, and were significantly (P < 0.05, P < 0.01) high in comparison with those in the lung. These results indicated that many healthy rats in the naturally infected colony harbored C. kutscheri, and the organisms colonized the oral cavity, esophagus, cecal contents, and colon and rectum most frequently.
Authors:
H Amao; Y Komukai; T Akimoto; M Sugiyama; K W Takahashi; T Sawada; M Saito
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Laboratory animal science     Volume:  45     ISSN:  0023-6764     ISO Abbreviation:  Lab. Anim. Sci.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-06-21     Completed Date:  1995-06-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1266503     Medline TA:  Lab Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  11-4     Citation Subset:  IM    
Affiliation:
Department of Laboratory Animal Science, Nippon Veterinary and Animal Science University, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Bacterial / blood
Carrier State
Cecum / microbiology
Colon / microbiology
Colony Count, Microbial
Corynebacterium / growth & development,  immunology,  isolation & purification*
Corynebacterium Infections / microbiology,  veterinary*
Esophagus / microbiology
Female
Male
Mouth / microbiology
Rats
Rats, Wistar
Rectum / microbiology
Rodent Diseases / microbiology*
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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