Document Detail

Natural products inhibiting Candida albicans secreted aspartic proteases from Tovomita krukovii.
MedLine Citation:
PMID:  11842327     Owner:  NLM     Status:  MEDLINE    
Assay-guided fractionation of the ethanol extract of Tovomita krukovii resulted in the identification of four new xanthones (1 - 4) and ten known compounds (5 - 14). The structures of compounds 1 - 14 were determined by spectral data to be 3,5-dihydroxy-4-methoxyxanthone (1), 1,3,5,7-tetrahydroxy-8-isoprenylxanthone (2), 1,3,5-trihydroxy-8-isoprenylxanthone (3), 1,5,7-trihydroxy-8-isoprenylxanthone (4), 1,3,7-trihydroxy-2-isoprenylxanthone (5), 1,5-dihydroxyxanthone (6), 1,6-dihydroxy-5-methoxyxanthone (7), 1,3,5-trihydroxyxanthone (8), 1,3,6-trihydroxy-5-methoxyxanthone (9), 1,6-dihydroxy-3,5-dimethoxyxanthone (10), 1,3,7-trihydroxyxanthone (11), 3-geranyl-2,4,6-trihydroxybenzophenone (12), betulinic acid (13), and 3,4-dihydroxybenzoic acid (14). Compounds 2, 3, 12 and 13 showed inhibitory effects against Candida albicans secreted aspartic proteases (SAP) with IC50 values of 15 microg/ml, 25 microg/ml, 40 microg/ml, and 6.5 microg/ml, respectively, while the other compounds were inactive. In addition, compound 12 showed activity against C. albicans, C. neoformans, S. aureus and methicillin resistant S. aureus (MRS).
Zhizhen Zhang; Hala N ElSohly; Melissa R Jacob; David S Pasco; Larry A Walker; Alice M Clark
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Planta medica     Volume:  68     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-13     Completed Date:  2002-05-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  49-54     Citation Subset:  IM    
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, Thad Cochran Research Center, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA.
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MeSH Terms
Antifungal Agents / chemistry,  isolation & purification,  pharmacology*
Aspartic Acid Endopeptidases / drug effects,  metabolism,  secretion
Candida albicans / drug effects*
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Pepsin A / drug effects,  metabolism
Plant Bark / chemistry
Plant Extracts / chemistry,  pharmacology
Plant Stems / chemistry
Xanthenes / chemistry,  isolation & purification,  pharmacology*
Grant Support
Reg. No./Substance:
0/3,5-dihydroxy-4-methoxy-xanthone; 0/Antifungal Agents; 0/Plant Extracts; 0/Xanthenes; 0/Xanthones; EC 3.4.23.-/Aspartic Acid Endopeptidases; EC A

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