| Natural products as aromatase inhibitors. | |
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MedLine Citation:
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PMID: 18690828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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With the clinical success of several synthetic aromatase inhibitors (AIs) in the treatment of postmenopausal estrogen receptor-positive breast cancer, researchers have also been investigating the potential of natural products as AIs. Natural products from terrestrial and marine organisms provide a chemically diverse array of compounds not always available through current synthetic chemistry techniques. Natural products that have been used traditionally for nutritional or medicinal purposes (e.g., botanical dietary supplements) may also afford AIs with reduced side effects. A thorough review of the literature regarding natural product extracts and secondary metabolites of plant, microbial, and marine origin that have been shown to exhibit aromatase inhibitory activity is presented herein. |
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Authors:
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Marcy J Balunas; Bin Su; Robert W Brueggemeier; A Douglas Kinghorn |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Anti-cancer agents in medicinal chemistry Volume: 8 ISSN: 1871-5206 ISO Abbreviation: Anticancer Agents Med Chem Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-11 Completed Date: 2008-10-01 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101265649 Medline TA: Anticancer Agents Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 646-82 Citation Subset: IM |
Affiliation:
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Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medical Chemistry and Pharnacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents, Hormonal / therapeutic use* Antineoplastic Agents, Phytogenic / therapeutic use Aromatase Inhibitors / therapeutic use* Biological Products / therapeutic use* Breast Neoplasms / drug therapy* Cell Extracts / therapeutic use Drug Evaluation, Preclinical Humans Models, Biological |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA073698-06/CA/NCI NIH HHS; R01 CA073698-08/CA/NCI NIH HHS; R01 CA73698/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Hormonal; 0/Antineoplastic Agents, Phytogenic; 0/Aromatase Inhibitors; 0/Biological Products; 0/Cell Extracts |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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