Document Detail

Natural products as aids for protecting the skin's immune system against UV damage.
MedLine Citation:
PMID:  15603219     Owner:  NLM     Status:  MEDLINE    
Modern sun-protection products reduce the risk for erythema and DNA damage, but even those products with a very high sun protection factor (SPF) and full-spectrum UVB and UVA protection may not prevent UV radiation (UVR)-induced immunomodulation. Formulating sunscreens with a high SPF, as well as a high immune protection factor, is necessary for preventing skin cancer and maintaining effective immune responses to infectious disease after sun exposure. Supplementing current sun-protection products with immunoprotective compounds may help fill the gap between erythema protection and immunoprotection. Animal and now human studies have shown that a class of agents known as oligosaccharins--complex carbohydrates found in plants--protect the cutaneous immune system from UVB-induced and UVA-induced immunomodulation. This immunoprotective effect occurs independently from erythema and DNA damage protection, and these agents, particularly tamarind xyloglucan, may become important adjunctive ingredients to sunscreens.
Faith M Strickland; Johanna M Kuchel; Gary M Halliday
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cutis     Volume:  74     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-12-17     Completed Date:  2005-03-18     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  24-8     Citation Subset:  IM    
Henry Ford Health System, Detroit, Michigan, USA.
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MeSH Terms
Immune Tolerance / drug effects*
Skin / immunology*
Skin Neoplasms / immunology,  prevention & control
Sunburn / prevention & control*
Ultraviolet Rays / adverse effects*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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