Document Detail


Natural products as aids for protecting the skin's immune system against UV damage.
MedLine Citation:
PMID:  15603219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Modern sun-protection products reduce the risk for erythema and DNA damage, but even those products with a very high sun protection factor (SPF) and full-spectrum UVB and UVA protection may not prevent UV radiation (UVR)-induced immunomodulation. Formulating sunscreens with a high SPF, as well as a high immune protection factor, is necessary for preventing skin cancer and maintaining effective immune responses to infectious disease after sun exposure. Supplementing current sun-protection products with immunoprotective compounds may help fill the gap between erythema protection and immunoprotection. Animal and now human studies have shown that a class of agents known as oligosaccharins--complex carbohydrates found in plants--protect the cutaneous immune system from UVB-induced and UVA-induced immunomodulation. This immunoprotective effect occurs independently from erythema and DNA damage protection, and these agents, particularly tamarind xyloglucan, may become important adjunctive ingredients to sunscreens.
Authors:
Faith M Strickland; Johanna M Kuchel; Gary M Halliday
Related Documents :
15556719 - Acne and sebaceous gland function.
15500639 - Anti-vascular endothelial growth factor receptor-2 (flk-1/kdr) antibody suppresses cont...
19576749 - Sulforaphane suppresses ultraviolet b-induced inflammation in hacat keratinocytes and h...
25041999 - Strail coupled to liposomes improves its pharmacokinetic profile and overcomes neurobla...
23300809 - Pi3k inhibition enhances doxorubicin-induced apoptosis in sarcoma cells.
11225199 - The antioxidant network of the stratum corneum.
23927879 - Suppression of t-cell activation in vitro and in vivo by cordycepin from cordyceps mili...
11870869 - Borna disease virus-induced accumulation of macrophage migration inhibitory factor in r...
7767949 - Comparative in vitro cytotoxic effects of taxol and its major human metabolite 6 alpha-...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cutis     Volume:  74     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-12-17     Completed Date:  2005-03-18     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  24-8     Citation Subset:  IM    
Affiliation:
Henry Ford Health System, Detroit, Michigan, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aloe
Animals
Humans
Immune Tolerance / drug effects*
Phytotherapy*
Skin / immunology*
Skin Neoplasms / immunology,  prevention & control
Sunburn / prevention & control*
Tamarindus
Ultraviolet Rays / adverse effects*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Methods used to evaluate the immune protection factor of a sunscreen: advantages and disadvantages o...
Next Document:  Identifying training needs of logging truck drivers using a skill inventory.