Document Detail


Natural photoreceptors and their application to synthetic biology.
MedLine Citation:
PMID:  25466878     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The ability to perturb living systems is essential to understand how cells sense, integrate, and exchange information, to comprehend how pathologic changes in these processes relate to disease, and to provide insights into therapeutic points of intervention. Several molecular technologies based on natural photoreceptor systems have been pioneered that allow distinct cellular signaling pathways to be modulated with light in a temporally and spatially precise manner. In this review, we describe and discuss the underlying design principles of natural photoreceptors that have emerged as fundamental for the rational design and implementation of synthetic light-controlled signaling systems. Furthermore, we examine the unique challenges that synthetic protein technologies face when applied to the study of neural dynamics at the cellular and network level.
Authors:
Daniel Schmidt; Yong Ku Cho
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Publication Detail:
Type:  REVIEW     Date:  2014-11-12
Journal Detail:
Title:  Trends in biotechnology     Volume:  -     ISSN:  1879-3096     ISO Abbreviation:  Trends Biotechnol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-3     Completed Date:  -     Revised Date:  2014-12-4    
Medline Journal Info:
Nlm Unique ID:  8310903     Medline TA:  Trends Biotechnol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Published by Elsevier Ltd.
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