Document Detail

Natural outcomes of stage 1, 2, 3, and 4 idiopathic macular holes.
MedLine Citation:
PMID:  7626565     Owner:  NLM     Status:  MEDLINE    
AIMS: A study was carried out to ascertain the natural outcome of each stage of idiopathic macular hole. METHODS: One hundred and fifty four eyes with different stages of idiopathic macular holes were retrospectively studied: stage 1 (40 eyes), 2 (25 eyes), 3 (58 eyes), and 4 (31 eyes). RESULTS: Of 27 of 40 eyes with a stage 1 lesion with posterior vitreous attachment to the macula initially, nine (33%) eyes developed a full thickness macular hole. No stage 1 lesions with posterior vitreous separation from the macula initially progressed to full thickness holes. Twenty one (84%) of 25 eyes with a stage 2 lesion, 32 (55%) of 58 eyes with a stage 3 lesion, and five (16%) of 31 eyes with a stage 4 lesion underwent macular hole enlargement during the median follow up period of 3 years. Visual acuity decreased two or more lines of Snellen equivalent during the follow up period in 12 (30%) eyes with a stage 1 lesion, 17 (68%) eyes with a stage 2 lesion, 17 (29%) eyes with a stage 3 lesion, and four (13%) eyes with a stage 4 lesion. The percentage was significantly higher in eyes with stage 2 lesions than the other stages (p < 0.01). CONCLUSION: The results suggest that the different stages of idiopathic macular holes have different natural outcomes, and the management depends on the stage at presentation.
T Hikichi; A Yoshida; J Akiba; C L Trempe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  79     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-09-07     Completed Date:  1995-09-07     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  517-20     Citation Subset:  IM    
Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
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MeSH Terms
Age Distribution
Aged, 80 and over
Disease Progression
Follow-Up Studies
Middle Aged
Retinal Perforations / pathology*,  physiopathology
Retrospective Studies
Sex Distribution
Visual Acuity
Comment In:
Br J Ophthalmol. 1995 Jun;79(6):511-2   [PMID:  7626562 ]

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