Document Detail

Natural noxious stimulation can induce long-term increase of spinal nociceptive responses.
MedLine Citation:
PMID:  10488682     Owner:  NLM     Status:  MEDLINE    
It is conceivable that plasticity in pain control systems and chronic pain may be due to mechanisms similar to learning. Long-term potentiation (LTP) in the hippocampus is often studied as a model of learning and memory. It has recently been shown that long-term excitation may be induced in single wide dynamic range (WDR) neurones in the spinal dorsal horn of rats after tetanic stimulation to the sciatic nerve. The present study shows that similar long-term changes can also be induced by a severe natural stimulus. Single unit extracellular recordings were made in urethane anaesthetized rats and the firing responses of WDR neurones evoked by a single electrical stimulus to the peripheral nerve were recorded every 4 min. After repeated crushing of tissue (including bone) corresponding to the receptive field of the WDR neurones (the conditioning stimulus) followed by a proximal total peripheral nerve block, the C-fibre evoked responses were increased (P < 0.001) for a 3 h observation period compared with baseline responses and control animals. In control animals the nerve block was applied before the conditioning stimulus. We suggest that a long-term increase of the excitability of WDR neurones may be important for the development of long lasting and chronic pain disorders after an acute but severe noxious stimulus.
L J Rygh; F Svendsen; K Hole; A Tjølsen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pain     Volume:  82     ISSN:  0304-3959     ISO Abbreviation:  Pain     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-19     Completed Date:  1999-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7508686     Medline TA:  Pain     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  305-10     Citation Subset:  IM    
Department of Physiology, University of Bergen, Norway.
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MeSH Terms
Analysis of Variance
Evoked Potentials / physiology
Long-Term Potentiation*
Pain / physiopathology*
Rats, Sprague-Dawley
Sciatic Nerve / physiology
Spinal Cord / physiopathology*

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