| Natural killer cell activity in coeliac disease: effect of in vitro treatment on effector lymphocytes and/or target lymphoblastoid, myeloid and epithelial cell lines with gliadin. | |
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MedLine Citation:
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PMID: 8768253 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To analyze the possible involvement of natural killer (NK) cell activity in the pathogenetic mechanism of coeliac disease (CD) we measured the spontaneous cytotoxic cell activity of peripheral blood mononuclear cells (PMNC) from patients with CD and from healthy donors. No significant differences were found between the NK cell activity of PMNC from healthy donors and from patients with CD using a standard 51 Cr release assay. However, a 30-min treatment of PMNC with gliadin inhibited NK cell activity in patients with CD. On the other hand, a 1-d incubation with gliadin induced cytotoxic cell activity of PMNC against the NK-resistant target cells such as the epithelial HT-29 and the lymphoblastoid RAJI cell lines, suggesting that activation of PMNC by cultivation with gliadin can occur. |
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Authors:
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M A Castany; H H Nguyen; M Pospísil; P Fric; H Tlaskalová-Hogenová |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Folia microbiologica Volume: 40 ISSN: 0015-5632 ISO Abbreviation: Folia Microbiol. (Praha) Publication Date: 1995 |
Date Detail:
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Created Date: 1996-09-24 Completed Date: 1996-09-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376757 Medline TA: Folia Microbiol (Praha) Country: CZECH REPUBLIC |
Other Details:
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Languages: eng Pagination: 615-20 Citation Subset: IM |
Affiliation:
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Department of Immunology and Gnotobiology, Academy of Sciences of the Czech Republic. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibody-Dependent Cell Cytotoxicity / drug effects Celiac Disease / immunology* Cells, Cultured Child Cytotoxicity, Immunologic / drug effects Gliadin / pharmacology* Humans Killer Cells, Natural / drug effects, immunology* Lymphocytes / drug effects* Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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9007-90-3/Gliadin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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