Document Detail


Natural killer cell activity in coeliac disease: effect of in vitro treatment on effector lymphocytes and/or target lymphoblastoid, myeloid and epithelial cell lines with gliadin.
MedLine Citation:
PMID:  8768253     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To analyze the possible involvement of natural killer (NK) cell activity in the pathogenetic mechanism of coeliac disease (CD) we measured the spontaneous cytotoxic cell activity of peripheral blood mononuclear cells (PMNC) from patients with CD and from healthy donors. No significant differences were found between the NK cell activity of PMNC from healthy donors and from patients with CD using a standard 51 Cr release assay. However, a 30-min treatment of PMNC with gliadin inhibited NK cell activity in patients with CD. On the other hand, a 1-d incubation with gliadin induced cytotoxic cell activity of PMNC against the NK-resistant target cells such as the epithelial HT-29 and the lymphoblastoid RAJI cell lines, suggesting that activation of PMNC by cultivation with gliadin can occur.
Authors:
M A Castany; H H Nguyen; M Pospísil; P Fric; H Tlaskalová-Hogenová
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Folia microbiologica     Volume:  40     ISSN:  0015-5632     ISO Abbreviation:  Folia Microbiol. (Praha)     Publication Date:  1995  
Date Detail:
Created Date:  1996-09-24     Completed Date:  1996-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376757     Medline TA:  Folia Microbiol (Praha)     Country:  CZECH REPUBLIC    
Other Details:
Languages:  eng     Pagination:  615-20     Citation Subset:  IM    
Affiliation:
Department of Immunology and Gnotobiology, Academy of Sciences of the Czech Republic.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibody-Dependent Cell Cytotoxicity / drug effects
Celiac Disease / immunology*
Cells, Cultured
Child
Cytotoxicity, Immunologic / drug effects
Gliadin / pharmacology*
Humans
Killer Cells, Natural / drug effects,  immunology*
Lymphocytes / drug effects*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
9007-90-3/Gliadin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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