| Natural killer cell activity in dermatomyositis-polymyositis. | |
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MedLine Citation:
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PMID: 3496455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the baseline natural killer (NK) function and its modulation by interleukin-2 (IL-2) in 16 patients with dermatomyositis/polymyositis (DM/PM). Patients with active untreated disease had low baseline NK activity, while in patients with inactive and untreated disease, it was akin to the controls. Patient's cells with low NK activity responded less to IL-2 than those with normal NK activity. Studies at the single cell level revealed decreased target binding and killing cells with a normal recycling capacity. Our findings indicate an association between disease activity and decreased NK function in patients with DM/PM that could play a role in its association with malignancy. |
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Authors:
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R Gonzalez-Amaro; J Alcocer-Varela; D Alarcón-Segovia |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of rheumatology Volume: 14 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 1987 Apr |
Date Detail:
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Created Date: 1987-08-10 Completed Date: 1987-08-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: CANADA |
Other Details:
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Languages: eng Pagination: 307-10 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cytotoxicity, Immunologic Dermatomyositis / immunology*, pathology Female Humans Interleukin-2 / pharmacology Killer Cells, Natural / immunology* Male Middle Aged Myositis / immunology*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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