Document Detail

Natural inhibitors of blood coagulation and fibrinolysis in patients with lupus anticoagulant.
MedLine Citation:
PMID:  1489897     Owner:  NLM     Status:  MEDLINE    
We studied the natural inhibitors (NI) of blood coagulation and fibrinolysis in 50 patients with lupus anticoagulant (LA), in order to identify possible alterations of these NI, that could favour thrombotic manifestations. We found no statistically significant difference in antithrombin III, protein C and alpha 2-antiplasmin between controls and patients with LA, irrespective of their clinical manifestations. We found an increase of plasminogen activator inhibitor (PAI, P < 0.001) and a decrease of free protein S (PSf, P < 0.001) and total protein S (PSt, 0.01 < P < 0.05) in the patients with LA when compared with the control group. We found no difference in the levels of NI between patients with thrombosis (n = 19) and without thrombosis (n = 31) nor between patients with (n = 25) or without thrombosis and/or foetal loss (n = 25). In contrast, we observed a decrease of PSf in women with foetal loss (n = 10) as compared with women without foetal loss (n = 22, 0.01 < P < 0.05) and a decrease of PSf when comparing 19 patients with systemic lupus erythematosus (SLE) with 31 patients without SLE (0.01 < P < 0.05). These findings show that the patients with LA had several abnormalities in the NI system, but there was no significant association between levels of PAI, PSf, PSt and a history of thrombosis.
L C Kordich; R R Forastiero; E Basilotta; P Porterie; L O Carreras
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  3     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-02-26     Completed Date:  1993-02-26     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  765-71     Citation Subset:  IM    
Department of Biological Chemistry, School of Exact and Natural Sciences, University of Buenos Aires, Argentina.
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MeSH Terms
Abortion, Habitual / blood*
Antithrombin III / analysis
Autoimmune Diseases / blood*
Blood Coagulation*
Hematologic Diseases / blood
Infection / blood
Lupus Coagulation Inhibitor / blood*
Lupus Erythematosus, Systemic / blood*
Middle Aged
Neoplasms / blood
Plasminogen Activator Inhibitor 1 / analysis
Protein C / analysis
Protein S / analysis
Thrombosis / blood*
alpha-2-Antiplasmin / analysis
Reg. No./Substance:
0/Lupus Coagulation Inhibitor; 0/Plasminogen Activator Inhibitor 1; 0/Protein C; 0/Protein S; 0/alpha-2-Antiplasmin; 9000-94-6/Antithrombin III

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